BRCC3 anticorps (C-Term)

N° du produit ABIN2788976

Cet anticorps Lapin Polyclonal détecte spécifiquement BRCC3 dans WB et IF. Il présente une réactivité envers Humain, Souris, Rat, Cheval, Porc, Boeuf (Vache), Cobaye et Lapin.

Aperçu rapide pour BRCC3 anticorps (C-Term) (ABIN2788976)

Antigène: BRCC3 (BRCA1/BRCA2-Containing Complex, Subunit 3 (BRCC3))

Reactivité: Humain, Souris, Rat, Cheval, Porc, Boeuf (Vache), Cobaye, Lapin

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp BRCC3 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF)

Détail du produit anti-BRCC3 anticorps

Épitope: C-Term

Séquence: HNGSVFTKNL CSQMSAVSGP LLQWLEDRLE QNQQHLQELQ QEKEELMQEL

Homologie: Cow: 93%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 93%, Pig: 100%, Rabbit: 93%, Rat: 86%

Attributs du produit: This is a rabbit polyclonal antibody against BRCC3. It was validated on Western Blot.

Purification: Affinity Purified

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 316 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur BRCC3

Antigène: BRCC3 (BRCA1/BRCA2-Containing Complex, Subunit 3 (BRCC3))

Autre désignation: BRCC3

Sujet: This gene encodes a subunit of the BRCA1-BRCA2-containing complex (BRCC), which is an E3 ubiquitin ligase. This complex plays a role in the DNA damage response, where it is responsible for the stable accumulation of BRCA1 at DNA break sites. The component encoded by this gene can specifically cleave Lys 63-linked polyubiquitin chains, and it regulates the abundance of these polyubiquitin chains in chromatin. The loss of this gene results in abnormal angiogenesis and is associated with syndromic moyamoya, a cerebrovascular angiopathy.
Alias Symbols: BRCC36, C6.1A, CXorf53, RP11-143H17.2
Protein Interaction Partner: FAM175B, UBC, FANCG, UIMC1, SUMO1, RABEP2, SMEK1, LARP7, CD2AP, WDHD1, SF3A1, GPHN, HNRNPR, TRIM28, HUWE1, MTA2, SPAG9, CCDC6, HDAC1, NR3C1, FAM175A, SUMO2, PAXIP1, MDC1, BRCA1, GRB2, BABAM1, BRE, BRCC3, COPS5, BACH1, BRCA2, BARD1, USP7, SHMT2, NDUFA10, M
Protein Size: 316

Poids moléculaire: 35 kDa

ID gène: 79184

NCBI Accession: NM_024332, NP_077308

UniProt: P46736

Pathways: Positive Regulation of Response to DNA Damage Stimulus