PRNP anticorps (Middle Region)

N° du produit ABIN2789398

Cet anticorps Lapin Polyclonal détecte spécifiquement PRNP dans WB et IHC. Il présente une réactivité avec des échantillons de Humain, Rat, Boeuf (Vache), Mouton, Chien et Chévre.

Aperçu rapide pour PRNP anticorps (Middle Region) (ABIN2789398)

Antigène: PRNP (Prion Protein (PRNP))

Reactivité: Humain, Rat, Boeuf (Vache), Mouton, Chien, Chévre

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PRNP est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Détail du produit anti-PRNP anticorps

Épitope: Middle Region

Fonction: Prnp Antibody - middle region

Séquence: GGGTHNQWNK PSKPKTNLKH VAGAAAAGAV VGGLGGYMLG SAMSRPMIHF

Homologie: Cow: 100%, Dog: 100%, Goat: 100%, Human: 100%, Rat: 100%, Sheep: 100%

Attributs du produit: This is a rabbit polyclonal antibody against Prnp. It was validated on Western Blot.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of Mouse Prnp

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP63174-100UG

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: prevent freeze-thaw cycles

Stock: 4 °C,-20 °C

Stockage commentaire: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Détails sur PRNP

Antigène: PRNP (Prion Protein (PRNP))

Autre désignation: Prnp

Sujet:

Background Information: Prnp may play a role in neuronal development and synaptic plasticity, may be required for neuronal myelin sheath maintenance and may play a role in iron uptake and iron homeostasis. Prnp is a soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. It also provides Cu2+ or ZN2+ for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains.

Gene Name: prion protein

Alternative Symbols: P, S, PrP, PrPC, Sinc, CD230, PrPSc, Prn-i, Prn-p, PrP, AA960666, AI325101, prP27-30, prP33-35C

Protein Name: Major prion protein

Poids moléculaire: 28kDa

ID gène: 19122

NCBI Accession: NP_035300

UniProt: P04925

Pathways: Transition Metal Ion Homeostasis, Activated T Cell Proliferation