Merlin anticorps (C-Term)

N° du produit ABIN2789402

Détail du produit anti-Merlin anticorps

Antigène: Merlin (NF2) (Neurofibromin 2 (NF2))

Épitope: C-Term

Reactivité: Humain, Souris, Rat, Poisson zèbre (Danio rerio), Chien, Boeuf (Vache), Cheval, Lapin, Cobaye

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Merlin est non-conjugé

Application: Western Blotting (WB)

Séquence: MAEESERRAK EADQLKQDLQ EAREAERRAK QKLLEIATKP TYPPMNPIPA

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%

Attributs du produit: This is a rabbit polyclonal antibody against NF2. It was validated on Western Blot.

Purification: Affinity Purified

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 507 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-Merlin (ABIN2789402)

Vasilyeva, Murzina, Kireev, Pivovarov: "Influence of Membrane Receptor Lateral Diffusion on the Short-Term Depression of Acetylcholine-Induced Current in Helix Neurons." dans: Cellular and molecular neurobiology, (2017) (PubMed).

Détails sur Merlin

Antigène: Merlin (NF2) (Neurofibromin 2 (NF2))

Autre désignation: NF2 (NF2 Produits)

Synonymes: anticorps ACN, anticorps BANF, anticorps SCH, anticorps NF2, anticorps merlin, anticorps zgc:194620, anticorps zgc:194631, anticorps NF2a, anticorps nf2, anticorps neurofibromin 2, anticorps neurofibromin 2a (merlin), anticorps neurofibromin 2b (merlin), anticorps neurofibromin 2 (merlin) S homeolog, anticorps NF2, anticorps Nf2, anticorps nf2a, anticorps nf2b, anticorps nf2.S

Sujet: This gene encodes a protein that is similar to some members of the ERM (ezrin, radixin, moesin) family of proteins that are thought to link cytoskeletal components with proteins in the cell membrane. This gene product has been shown to interact with cell-surface proteins, proteins involved in cytoskeletal dynamics and proteins involved in regulating ion transport. This gene is expressed at high levels during embryonic development, in adults, significant expression is found in Schwann cells, meningeal cells, lens and nerve. Mutations in this gene are associated with neurofibromatosis type II which is characterized by nervous system and skin tumors and ocular abnormalities. Two predominant isoforms and a number of minor isoforms are produced by alternatively spliced transcripts.
Alias Symbols: ACN, BANF, SCH
Protein Interaction Partner: VPRBP, CD44, UBC, KDM1A, AMOTL2, YAP1, PPP1R8, UBD, CCNB1IP1, HGS, CUL4A, DDB1, GPS1, WWC1, PYGO2, AMOT, SCHIP1, SGSM3, NF2, TSC1, TARBP2, SLC9A3R1, PAK1, XPO1, PXN, SDCBP, RALGDS, SPTBN1, ERBB2, ITGB1, EZR, CTNNB1, AGAP2, AKT1, RIT1, ARHGAP32, SOS1, MED2
Protein Size: 507

Poids moléculaire: 56 kDa

ID gène: 4771

NCBI Accession: NM_181830, NP_861968

Pathways: Cell-Cell Junction Organization