MC1 Receptor anticorps (C-Term)

N° du produit ABIN2789427

Cet anticorps Lapin Polyclonal détecte spécifiquement MC1 Receptor dans WB. Il présente une réactivité envers Humain, Souris, Rat, Porc et Lapin.

Aperçu rapide pour MC1 Receptor anticorps (C-Term) (ABIN2789427)

Antigène: MC1 Receptor (MC1R) (Melanocortin 1 Receptor (MC1R))

Reactivité: Humain, Souris, Rat, Porc, Lapin

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MC1 Receptor est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-MC1 Receptor anticorps

Épitope: C-Term

Séquence: CPEHPTCGCI FKNFNLFLAL IICNAIIDPL IYAFHSQELR RTLKEVLTCS

Homologie: Human: 100%, Mouse: 86%, Pig: 93%, Rabbit: 93%, Rat: 93%

Attributs du produit: This is a rabbit polyclonal antibody against MC1R. It was validated on Western Blot.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the C-terminal region of MC1R

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 317 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur MC1 Receptor

Antigène: MC1 Receptor (MC1R) (Melanocortin 1 Receptor (MC1R))

Autre désignation: MC1R

Sujet: This intronless gene encodes the receptor protein for melanocyte-stimulating hormone (MSH). The encoded protein, a seven pass transmembrane G protein coupled receptor, controls melanogenesis. Two types of melanin exist: red pheomelanin and black eumelanin. Gene mutations that lead to a loss in function are associated with increased pheomelanin production, which leads to lighter skin and hair color. Eumelanin is photoprotective but pheomelanin may contribute to UV-induced skin damage by generating free radicals upon UV radiation. Binding of MSH to its receptor activates the receptor and stimulates eumelanin synthesis. This receptor is a major determining factor in sun sensitivity and is a genetic risk factor for melanoma and non-melanoma skin cancer. Over 30 variant alleles have been identified which correlate with skin and hair color, providing evidence that this gene is an important component in determining normal human pigment variation.
Alias Symbols: CMM5, MGC14337, MSH-R, SHEP2
Protein Interaction Partner: SUMO2, RIC8A, OGFOD1, TRNT1, EZR, UBA1, PYGL, AHCY, UBC, MGRN1, ASIP, POMC, MC4R,
Protein Size: 317

Poids moléculaire: 35 kDa

ID gène: 4157

NCBI Accession: NM_002386, NP_002377

UniProt: Q01726

Pathways: cAMP Metabolic Process, Feeding Behaviour