VKORC1 anticorps (N-Term)

N° du produit ABIN2789450

Cet anticorps anti-VKORC1 Polyclonal Lapin (ABIN2789450) détecte spécifiquement VKORC1 dans WB et IHC. L’anticorps est réactif avec des échantillons de Humain, Souris, Rat, Boeuf (Vache), Lapin, Chien, Cobaye et Cheval.

Aperçu rapide pour VKORC1 anticorps (N-Term) (ABIN2789450)

Antigène: VKORC1 (Vitamin K Epoxide Reductase Complex, Subunit 1 (VKORC1))

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Lapin, Chien, Cobaye, Cheval

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp VKORC1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Détail du produit anti-VKORC1 anticorps

Épitope: N-Term

Fonction: VKORC1 Antibody - N-terminal region

Séquence: LHVKAARARD RDYRALCDVG TAISCSRVFS SRLPADTLGL CPDAAELPGV

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 93%, Horse: 93%, Human: 100%, Mouse: 86%, Rabbit: 100%, Rat: 86%

Attributs du produit: This is a rabbit polyclonal antibody against VKORC1. It was validated on Western Blot.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N-terminal region of VKORC1

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP63330-100UG

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: prevent freeze-thaw cycles

Stock: 4 °C,-20 °C

Stockage commentaire: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Détails sur VKORC1

Antigène: VKORC1 (Vitamin K Epoxide Reductase Complex, Subunit 1 (VKORC1))

Autre désignation: VKORC1

Sujet:

Targeted Subunit: 1

Background Information: Vitamin K is essential for blood clotting but must be enzymatically activated. This enzymatically activated form of vitamin K is a reduced form required for the carboxylation of glutamic acid residues in some blood-clotting proteins. The product of this gene encodes the enzyme that is responsible for reducing vitamin K 2,3-epoxide to the enzymatically activated form. Fatal bleeding can be caused by vitamin K deficiency and by the vitamin K antagonist warfarin, and it is the product of this gene that is sensitive to warfarin. In humans, mutations in this gene can be associated with deficiencies in vitamin-K-dependent clotting factors and, in humans and rats, with warfarin resistance. Two pseudogenes have been identified on chromosome 1 and the X chromosome. Two alternatively spliced transcripts encoding different isoforms have been described.

Alternative Symbols: VKOR, MST134, MST576, VKCFD2, EDTP308

Protein Name: Vitamin K epoxide reductase complex subunit 1

Poids moléculaire: 10kDa

ID gène: 79001

NCBI Accession: NP_996560

UniProt: Q9BQB6