KIR2DS2 anticorps (N-Term)

N° du produit ABIN2789655

L’anticorps anti-KIR2DS2 Polyclonal Lapin est utilisé pour la détection de KIR2DS2 dans des échantillons de Humain. Il a été validé pour WB.

Aperçu rapide pour KIR2DS2 anticorps (N-Term) (ABIN2789655)

Antigène: KIR2DS2 (Killer Cell Immunoglobulin-Like Receptor 2DS2 (KIR2DS2))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp KIR2DS2 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-KIR2DS2 anticorps

Épitope: N-Term

Fonction: KIR2DS2 Antibody - N-terminal region

Séquence: ETVILQCWSD VRFEHFLLHR EGKYKDTLHL IGEHHDGVSK ANFSIGPMMQ

Homologie: Human: 100%

Attributs du produit: This is a rabbit polyclonal antibody against KIR2DS2. It was validated on Western Blot.

Purification: Affinity Purified

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP63891-100UG

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: prevent freeze-thaw cycles

Stock: 4 °C,-20 °C

Stockage commentaire: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Détails sur KIR2DS2

Antigène: KIR2DS2 (Killer Cell Immunoglobulin-Like Receptor 2DS2 (KIR2DS2))

Autre désignation: KIR2DS2

Sujet:

Background Information: Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules, thus, KIR proteins are thought to play an important role in regulation of the immune response.

Gene Name: Killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 2

Alternative Symbols: NKAT5, cl-49, CD158J, CD158b, NKAT-5, 183ActI, KIR2DL1, KIR-2DS2

Protein Name: KIR2DS2 EMBL ACX71621.1

Poids moléculaire: 32kDa

ID gène: 100132285

NCBI Accession: NP_036444

UniProt: D0UWM7