PICALM anticorps (Middle Region)
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- Antigène Voir toutes PICALM Anticorps
- PICALM (Phosphatidylinositol Binding clathrin Assembly Protein (PICALM))
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Épitope
- Middle Region
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Reactivité
- Humain, Souris, Rat, Boeuf (Vache), Chien, Cobaye, Cheval, Lapin, Poisson zèbre (Danio rerio)
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp PICALM est non-conjugé
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Application
- Western Blotting (WB)
- Séquence
- ALEQHLASLE GKKIKDSTAA SRATTLSNAV SSLASTGLSL TKVDEREKQA
- Homologie
- Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 93%
- Attributs du produit
- This is a rabbit polyclonal antibody against PICALM. It was validated on Western Blot.
- Purification
- Affinity Purified
- Top Product
- Discover our top product PICALM Anticorps primaire
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- Indications d'application
- Optimal working dilutions should be determined experimentally by the investigator.
- Commentaires
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Antigen size: 652 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
- Stock
- -20 °C
- Stockage commentaire
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Antigène
- PICALM (Phosphatidylinositol Binding clathrin Assembly Protein (PICALM))
- Autre désignation
- PICALM (PICALM Produits)
- Sujet
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This gene encodes a clathrin assembly protein, which recruits clathrin and adaptor protein complex 2 (AP2) to cell membranes at sites of coated-pit formation and clathrin-vesicle assembly. The protein may be required to determine the amount of membrane to be recycled, possibly by regulating the size of the clathrin cage. The protein is involved in AP2-dependent clathrin-mediated endocytosis at the neuromuscular junction. A chromosomal translocation t(10,11)(p13,q14) leading to the fusion of this gene and the MLLT10 gene is found in acute lymphoblastic leukemia, acute myeloid leukemia and malignant lymphomas. The polymorphisms of this gene are associated with the risk of Alzheimer disease.
Alias Symbols: CALM, CLTH, LAP
Protein Interaction Partner: UBC, PELI2, VCAM1, ITGA4, FN1, SIRT1, ILF3, EGFR, EEF1A1, DNM2, CD55, ABCC2, ATP6V1E1, AP2A1, SH3GLB2, FLOT1, HNRNPDL, SEC24D, SEC24C, ATP6V1F, HIP1R, LAMTOR3, ITSN1, EHD2, CASP8, CLTCL1, CASP3, PLCG1, DDIT3, CLTC,
Protein Size: 652 - Poids moléculaire
- 71 kDa
- ID gène
- 8301
- NCBI Accession
- NM_007166, NP_009097
- UniProt
- Q13492
- Pathways
- Synaptic Membrane
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