UNC13D anticorps (C-Term)

N° du produit ABIN2789769

L’anticorps Lapin Polyclonal anti-UNC13D a été validé pour WB. Il convient pour détecter UNC13D dans des échantillons de Humain, Souris, Rat, Chien, Lapin, Boeuf (Vache), Cobaye et Cheval.

Aperçu rapide pour UNC13D anticorps (C-Term) (ABIN2789769)

Antigène: UNC13D (Unc-13 Homolog D (UNC13D))

Reactivité: Humain, Souris, Rat, Chien, Lapin, Boeuf (Vache), Cobaye, Cheval

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp UNC13D est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-UNC13D anticorps

Épitope: C-Term

Séquence: SGSEEPGEVP QTRLPLTYPA PNGDPILQLL EGRKGDREAQ VFVRLRRHRA

Homologie: Cow: 92%, Dog: 93%, Guinea Pig: 92%, Horse: 93%, Human: 100%, Mouse: 92%, Rabbit: 86%, Rat: 100%

Attributs du produit: This is a rabbit polyclonal antibody against UNC13D. It was validated on Western Blot.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the C-terminal region of Human UNC13D

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeat freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur UNC13D

Antigène: UNC13D (Unc-13 Homolog D (UNC13D))

Autre désignation: UNC13D

Sujet: This gene encodes a protein that is a member of the UNC13 family, containing similar domain structure as other family members but lacking an N-terminal phorbol ester-binding C1 domain present in other Munc13 proteins. The protein appears to play a role in vesicle maturation during exocytosis and is involved in regulation of cytolytic granules secretion. Mutations in this gene are associated with familial hemophagocytic lymphohistiocytosis type 3, a genetically heterogeneous, rare autosomal recessive disorder.
Alias Symbols: FHL3, HLH3, HPLH3, Munc13-4
Protein Interaction Partner: UBC, CUL5, VPS37B, XRN2, LMNA, RAB27B, RAB27A,
Protein Size: 1090

Poids moléculaire: 119 kDa

ID gène: 201294

NCBI Accession: NM_199242, NP_954712

UniProt: Q70J99

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process