UNC13D anticorps (C-Term)

N° du produit ABIN2789769

Détail du produit anti-UNC13D anticorps

Antigène: UNC13D (Unc-13 Homolog D (UNC13D))

Épitope: C-Term

Reactivité: Humain, Souris, Rat, Chien, Boeuf (Vache), Lapin, Cobaye, Cheval

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp UNC13D est non-conjugé

Application: Western Blotting (WB)

Séquence: SGSEEPGEVP QTRLPLTYPA PNGDPILQLL EGRKGDREAQ VFVRLRRHRA

Homologie: Cow: 92%, Dog: 93%, Guinea Pig: 92%, Horse: 93%, Human: 100%, Mouse: 92%, Rabbit: 86%, Rat: 100%

Attributs du produit: This is a rabbit polyclonal antibody against UNC13D. It was validated on Western Blot.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the C-terminal region of Human UNC13D

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeat freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur UNC13D

Antigène: UNC13D (Unc-13 Homolog D (UNC13D))

Autre désignation: UNC13D (UNC13D Produits)

Synonymes: anticorps FHL3, anticorps HLH3, anticorps HPLH3, anticorps Munc13-4, anticorps UNC13D, anticorps 2610108D09Rik, anticorps Jinx, anticorps mFLJ00067, anticorps Unc13h4, anticorps BIGH3, anticorps CDB1, anticorps CDG2, anticorps CDGG1, anticorps CSD, anticorps CSD1, anticorps CSD2, anticorps CSD3, anticorps EBMD, anticorps LCD1, anticorps unc-13 homolog D, anticorps unc-13 homolog D (C. elegans), anticorps transforming growth factor beta induced, anticorps UNC13D, anticorps Unc13d, anticorps TGFBI, anticorps unc13d, anticorps un13d

Sujet: This gene encodes a protein that is a member of the UNC13 family, containing similar domain structure as other family members but lacking an N-terminal phorbol ester-binding C1 domain present in other Munc13 proteins. The protein appears to play a role in vesicle maturation during exocytosis and is involved in regulation of cytolytic granules secretion. Mutations in this gene are associated with familial hemophagocytic lymphohistiocytosis type 3, a genetically heterogeneous, rare autosomal recessive disorder.
Alias Symbols: FHL3, HLH3, HPLH3, Munc13-4
Protein Interaction Partner: UBC, CUL5, VPS37B, XRN2, LMNA, RAB27B, RAB27A,
Protein Size: 1090

Poids moléculaire: 119 kDa

ID gène: 201294

NCBI Accession: NM_199242, NP_954712

UniProt: Q70J99

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process