DEF6 anticorps (C-Term)

N° du produit ABIN2790082

Cet anticorps anti-DEF6 est un anticorps Lapin Polyclonal détectant DEF6 dans WB. Adapté pour Humain, Souris, Rat, Chien, Porc, Boeuf (Vache), Cobaye, Cheval et Lapin.

Aperçu rapide pour DEF6 anticorps (C-Term) (ABIN2790082)

Antigène: DEF6 (Differentially Expressed in FDCP 6 Homolog (DEF6))

Reactivité: Humain, Souris, Rat, Chien, Porc, Boeuf (Vache), Cobaye, Cheval, Lapin

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp DEF6 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-DEF6 anticorps

Épitope: C-Term

Séquence: QERYIERAQQ EKEELQQEMA QQSRSLQQAQ QQLEEVRQNR QRADEDVEAA

Homologie: Cow: 93%, Dog: 93%, Guinea Pig: 83%, Horse: 93%, Human: 100%, Mouse: 93%, Pig: 90%, Rabbit: 93%, Rat: 93%

Attributs du produit: This is a rabbit polyclonal antibody against DEF6. It was validated on Western Blot.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the C-terminal region of human BRCC3

Information d'application

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeat freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur DEF6

Antigène: DEF6 (Differentially Expressed in FDCP 6 Homolog (DEF6))

Autre désignation: DEF6

Sujet: This gene encodes a subunit of the BRCA1-BRCA2-containing complex (BRCC), which is an E3 ubiquitin ligase. This complex plays a role in the DNA damage response, where it is responsible for the stable accumulation of BRCA1 at DNA break sites. The component encoded by this gene can specifically cleave Lys 63-linked polyubiquitin chains, and it regulates the abundance of these polyubiquitin chains in chromatin. The loss of this gene results in abnormal angiogenesis and is associated with syndromic moyamoya, a cerebrovascular angiopathy. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 5.
Alias Symbols: C6.1A, BRCC36, CXorf53
Protein Size: 376

Poids moléculaire: 41 kDa

ID gène: 79184

NCBI Accession: NM_001018055, NP_001018065

UniProt: P46736