SPAG1 anticorps (N-Term)

N° du produit ABIN2790231

L’anticorps anti-SPAG1 Polyclonal Lapin est utilisé pour la détection de SPAG1 dans des échantillons de Humain et Chien. Il a été validé pour WB.

Aperçu rapide pour SPAG1 anticorps (N-Term) (ABIN2790231)

Antigène: SPAG1 (Sperm Associated Antigen 1 (SPAG1))

Reactivité: Humain, Chien

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SPAG1 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-SPAG1 anticorps

Épitope: N-Term

Séquence: LHVGKEKYSK RPTKKKTPRD YAEWDKFDVE KECLKIDEDY KEKTVIDKSH

Homologie: Dog: 85%, Human: 100%

Attributs du produit: This is a rabbit polyclonal antibody against SPAG1. It was validated on Western Blot.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N-terminal region of human SPAG1

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeat freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur SPAG1

Antigène: SPAG1 (Sperm Associated Antigen 1 (SPAG1))

Autre désignation: SPAG1

Sujet: The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies in blocking fertilization. Improved diagnosis and treatment of immunologic infertility, as well as identification of proteins for targeted contraception, are dependent on the identification and characterization of relevant sperm antigens. The protein expressed by this gene is recognized by anti-sperm agglutinating antibodies from an infertile woman. Furthermore, immunization of female rats with the recombinant human protein reduced fertility. This protein localizes to the plasma membrane of germ cells in the testis and to the post-acrosomal plasma membrane of mature spermatozoa. Recombinant polypeptide binds GTP and exhibits GTPase activity. Thus, this protein may regulate GTP signal transduction pathways involved in spermatogenesis and fertilization. Two transcript variants of this gene encode the same protein.
Alias Symbols: SP75, TPIS, CT140, CILD28, HSD-3.8, HEL-S-268
Protein Size: 416

Poids moléculaire: 45 kDa

ID gène: 6674

NCBI Accession: NM_003114, NP_003105

UniProt: G3XAM3