POLR3G anticorps (Middle Region)

N° du produit ABIN2791063

Détail du produit anti-POLR3G anticorps

Antigène: POLR3G (Polymerase (RNA) III (DNA Directed) Polypeptide G (32kD) (POLR3G))

Épitope: Middle Region

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp POLR3G est non-conjugé

Application: Western Blotting (WB)

Séquence: SKRYMKVYKE EWIPDWRRLP REMMPRNKCK KAGPKPKKAK DAGKGTPLTN

Homologie: Human: 100%

Attributs du produit: This is a rabbit polyclonal antibody against POLR3G. It was validated on Western Blot.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of Human POLR3G

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 223 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur POLR3G

Antigène: POLR3G (Polymerase (RNA) III (DNA Directed) Polypeptide G (32kD) (POLR3G))

Autre désignation: POLR3G (POLR3G Produits)

Synonymes: anticorps 2310047G20Rik, anticorps AV275904, anticorps RPC32, anticorps RPC7, anticorps polymerase (RNA) III (DNA directed) polypeptide G, anticorps RNA polymerase III subunit G, anticorps Polr3g, anticorps POLR3G

Sujet: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. POLR3G is a specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. It may direct with other members of the RPC3/POLR3C-RPC6/POLR3F-RPC7/POLR3G subcomplex RNA Pol III binding to the TFIIIB-DNA complex via the interactions between TFIIIB and POLR3F. It may be involved either in the recruitment and stabilization of the subcomplex within RNA polymerase III, or in stimulating catalytic functions of other subunits during initiation. POLR3G plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. POLR3G acts as nuclear and cytosolic DNA sensor involved in innate immune response. POLR3G can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway.
Alias Symbols: RPC32, RPC7
Protein Interaction Partner: RBM28, POLR3C, POLR3F, POLR2C, UBC, POLR3H, POLR3D,
Protein Size: 223

Poids moléculaire: 26 kDa

ID gène: 10622

NCBI Accession: NM_006467, NP_006458

UniProt: O15318