RRP8 anticorps (N-Term)

N° du produit ABIN2791072

Cet anticorps anti-RRP8 Polyclonal Lapin (ABIN2791072) détecte spécifiquement RRP8 dans WB. L’anticorps est réactif avec des échantillons de Humain, Rat, Boeuf (Vache), Cheval, Lapin, Cobaye, Chien et Saccharomyces cerevisiae.

Aperçu rapide pour RRP8 anticorps (N-Term) (ABIN2791072)

Antigène: RRP8 (Ribosomal RNA Processing 8 (RRP8))

Reactivité: Humain, Rat, Boeuf (Vache), Cheval, Lapin, Cobaye, Chien, Saccharomyces cerevisiae

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RRP8 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-RRP8 anticorps

Épitope: N-Term

Fonction: RRP8 Antibody - N-terminal region

Séquence: GPPCSDSEEE VERKKKCHKQ ALVGSDSAED EKRKRKCQKH APINSAQHLD

Homologie: Cow: 80%, Dog: 85%, Guinea Pig: 91%, Horse: 85%, Human: 100%, Rabbit: 100%, Rat: 93%, Yeast: 90%

Attributs du produit: This is a rabbit polyclonal antibody against RRP8. It was validated on Western Blot.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N-terminal region of Human RRP8

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP68567-100UG

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: prevent freeze-thaw cycles

Stock: 4 °C,-20 °C

Stockage commentaire: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Détails sur RRP8

Antigène: RRP8 (Ribosomal RNA Processing 8 (RRP8))

Autre désignation: RRP8

Sujet:

Background Information: RRP8 is an essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD+/NADP+ ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase. Its substrates are however unknown.

Alternative Symbols: NML, KIAA0409

Protein Name: Ribosomal RNA-processing protein 8

Poids moléculaire: 50kDa

ID gène: 23378

NCBI Accession: NP_056139

UniProt: O43159