MACROD1 anticorps (N-Term)

N° du produit ABIN2791083

Cet anticorps anti-MACROD1 Polyclonal Lapin (ABIN2791083) détecte spécifiquement MACROD1 dans WB. L’anticorps est réactif avec des échantillons de Humain, Boeuf (Vache), Chien, Cobaye, Cheval, Souris et Rat.

Aperçu rapide pour MACROD1 anticorps (N-Term) (ABIN2791083)

Antigène: MACROD1 (MACRO Domain Containing 1 (MACROD1))

Reactivité: Humain, Boeuf (Vache), Chien, Cobaye, Cheval, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MACROD1 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-MACROD1 anticorps

Épitope: N-Term

Fonction: MACROD1 Antibody - N-terminal region

Séquence: MAAKVDLSTS TDWKEAKSFL KGLSDKQREE HYFCKDFVRL KKIPTWKEMA

Homologie: Cow: 100%, Dog: 92%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rat: 100%

Attributs du produit: This is a rabbit polyclonal antibody against MACROD1. It was validated on Western Blot.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N-terminal region of Human MACROD1

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP68610-100UG

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: prevent freeze-thaw cycles

Stock: 4 °C,-20 °C

Stockage commentaire: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Détails sur MACROD1

Antigène: MACROD1 (MACRO Domain Containing 1 (MACROD1))

Autre désignation: MACROD1

Sujet:

Background Information: MACROD1 deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins. It plays a role in estrogen signaling. Binds to androgen receptor (AR) and amplifies the transactivation function of AR in response to androgen and may play an important role in carcinogenesis and/or progression of hormone-dependent cancers by feed-forward mechanism that activates ESR1 transactivation. It could be an ESR1 coactivator, providing a positive feedback regulatory loop for ESR1 signal transduction and could be involved in invasive growth by down-regulating CDH1 in endometrial cancer cells. MACROD1 enhances ESR1-mediated transcription activity.

Alternative Symbols: LRP16

Protein Name: O-acetyl-ADP-ribose deacetylase MACROD1

Poids moléculaire: 36kDa

ID gène: 28992

NCBI Accession: NP_054786

UniProt: Q9BQ69