MACROD1 anticorps (N-Term)

N° du produit ABIN2791083

Détail du produit anti-MACROD1 anticorps

Antigène: MACROD1 (MACRO Domain Containing 1 (MACROD1))

Épitope: N-Term

Reactivité: Humain, Boeuf (Vache), Chien, Cobaye, Cheval, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MACROD1 est non-conjugé

Application: Western Blotting (WB)

Séquence: MAAKVDLSTS TDWKEAKSFL KGLSDKQREE HYFCKDFVRL KKIPTWKEMA

Homologie: Cow: 100%, Dog: 92%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rat: 100%

Attributs du produit: This is a rabbit polyclonal antibody against MACROD1. It was validated on Western Blot.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N-terminal region of Human MACROD1

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 325 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur MACROD1

Antigène: MACROD1 (MACRO Domain Containing 1 (MACROD1))

Autre désignation: MACROD1 (MACROD1 Produits)

Synonymes: anticorps lrp16, anticorps d930010j01rik, anticorps LRP16, anticorps AI604841, anticorps AW743046, anticorps D930010J01Rik, anticorps Lrp16, anticorps MACRO domain containing 1, anticorps MACRO domain containing 1 L homeolog, anticorps MACROD1, anticorps macrod1, anticorps macrod1.L, anticorps Macrod1

Sujet: MACROD1 deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins. It plays a role in estrogen signaling. Binds to androgen receptor (AR) and amplifies the transactivation function of AR in response to androgen and may play an important role in carcinogenesis and/or progression of hormone-dependent cancers by feed-forward mechanism that activates ESR1 transactivation. It could be an ESR1 coactivator, providing a positive feedback regulatory loop for ESR1 signal transduction and could be involved in invasive growth by down-regulating CDH1 in endometrial cancer cells. MACROD1 enhances ESR1-mediated transcription activity.
Alias Symbols: LRP16
Protein Interaction Partner: BAG3, EPB41,
Protein Size: 325

Poids moléculaire: 36 kDa

ID gène: 28992

NCBI Accession: NM_014067, NP_054786

UniProt: Q9BQ69