Spartan anticorps (C-Term)

N° du produit ABIN2791211

Cet anticorps anti-Spartan est un anticorps Lapin Polyclonal détectant Spartan dans WB. Adapté pour Humain.

Aperçu rapide pour Spartan anticorps (C-Term) (ABIN2791211)

Antigène: Spartan (C1orf124) (Chromosome 1 Open Reading Frame 124 (C1orf124))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Spartan est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-Spartan anticorps

Épitope: C-Term

Séquence: QIKSSGNDPK YSTTTAQNSS SSSSQSKMVN CPVCQNEVLE SQINEHLDWC

Homologie: Human: 100%

Attributs du produit: This is a rabbit polyclonal antibody against SPRTN. It was validated on Western Blot.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the C-terminal region of Human SPRTN

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeat freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur Spartan

Antigène: Spartan (C1orf124) (Chromosome 1 Open Reading Frame 124 (C1orf124))

Autre désignation: SPRTN

Sujet: SPRTN is a regulator of UV-induced DNA damage response: acts as a 'reader' of ubiquitinated PCNA that enhances RAD18-mediated PCNA ubiquitination and translesion DNA synthesis. SPRTN is recruited to sites of UV damage and interacts with ubiquitinated PCNA and RAD18, the E3 ubiquitin ligase that monoubiquitinates PCNA. It facilitates chromatin association of RAD18 and is required for efficient PCNA monoubiquitination, promoting a feed-forward loop to enhance PCNA ubiquitination and translesion DNA synthesis. It is also required for localization of DNA polymerase eta (POLH) to sites of UV damage.
Alias Symbols: C1orf124, DDDL1880, PRO4323, Spartan, dJ876B10.3
Protein Interaction Partner: H2BFS, UBR5, FAM120A, STRAP, CKAP4, MAGED2, HIST2H2BF, HIST1H2BK, POLD4, ZC3HAV1, POLD3, DDX17, SYNCRIP, TRIM28, LRPPRC, HUWE1, HNRNPDL, AKAP12, RBM39, H1FX, HIST1H2BH, HIST1H2BM, HIST1H2BN, HIST1H2BL, HIST1H2BG, VIM, VDAC1, UBB, TUFM, DNAJC7, TMPO, STAU1
Protein Size: 489

Poids moléculaire: 55 kDa

ID gène: 83932

NCBI Accession: NM_032018, NP_114407

UniProt: Q9H040