Spartan anticorps (C-Term)

N° du produit ABIN2505865

Détail du produit anti-Spartan anticorps

Antigène: Spartan (C1orf124) (Chromosome 1 Open Reading Frame 124 (C1orf124))

Épitope: C-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Spartan est non-conjugé

Application: Western Blotting (WB)

Séquence: QIKSSGNDPK YSTTTAQNSS SSSSQSKMVN CPVCQNEVLE SQINEHLDWC

Homologie: Human: 100%

Attributs du produit: This is a rabbit polyclonal antibody against SPRTN. It was validated on Western Blot.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the C-terminal region of Human SPRTN

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeat freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur Spartan

Antigène: Spartan (C1orf124) (Chromosome 1 Open Reading Frame 124 (C1orf124))

Autre désignation: SPRTN (C1orf124 Produits)

Synonymes: anticorps Spartan, anticorps c1orf124, anticorps C1orf124, anticorps DDDL1880, anticorps DVC1, anticorps PRO4323, anticorps dJ876B10.3, anticorps C28H1orf124, anticorps SprT-like N-terminal domain, anticorps sprtn, anticorps SPRTN

Sujet: SPRTN is a regulator of UV-induced DNA damage response: acts as a 'reader' of ubiquitinated PCNA that enhances RAD18-mediated PCNA ubiquitination and translesion DNA synthesis. SPRTN is recruited to sites of UV damage and interacts with ubiquitinated PCNA and RAD18, the E3 ubiquitin ligase that monoubiquitinates PCNA. It facilitates chromatin association of RAD18 and is required for efficient PCNA monoubiquitination, promoting a feed-forward loop to enhance PCNA ubiquitination and translesion DNA synthesis. It is also required for localization of DNA polymerase eta (POLH) to sites of UV damage.
Alias Symbols: C1orf124, DDDL1880, PRO4323, Spartan, dJ876B10.3
Protein Interaction Partner: H2BFS, UBR5, FAM120A, STRAP, CKAP4, MAGED2, HIST2H2BF, HIST1H2BK, POLD4, ZC3HAV1, POLD3, DDX17, SYNCRIP, TRIM28, LRPPRC, HUWE1, HNRNPDL, AKAP12, RBM39, H1FX, HIST1H2BH, HIST1H2BM, HIST1H2BN, HIST1H2BL, HIST1H2BG, VIM, VDAC1, UBB, TUFM, DNAJC7, TMPO, STAU1
Protein Size: 489

Poids moléculaire: 55 kDa

ID gène: 83932

NCBI Accession: NM_032018, NP_114407

UniProt: Q9H040