VHLL anticorps (N-Term)

N° du produit ABIN2791981

Cet anticorps Lapin Polyclonal détecte spécifiquement VHLL dans WB. Il présente une réactivité envers Humain.

Aperçu rapide pour VHLL anticorps (N-Term) (ABIN2791981)

Antigène: VHLL (Von Hippel-Lindau Tumor Suppressor-Like (VHLL))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp VHLL est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-VHLL anticorps

Épitope: N-Term

Séquence: PWRAGNGVGL EAQAGTQEAG PEEYCQEELG AEEEMAARAA WPVLRSVNSR

Homologie: Human: 100%

Attributs du produit: This is a rabbit polyclonal antibody against VHLL. It was validated on Western Blot.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N-terminal region of Human VHLL

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeat freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur VHLL

Antigène: VHLL (Von Hippel-Lindau Tumor Suppressor-Like (VHLL))

Autre désignation: VHLL

Sujet: Von Hippel-Lindau (VHL) tumor suppressor protein is a component of an E3 ubiquitin ligase complex that selectively ubiquitinates the alpha subunit of the hypoxia-inducible factor (HIF) transcription factor for proteasome-mediated degradation. Inactivation of VHL causes VHL disease and sporadic kidney cancer. This gene encodes a VHL homolog that lacks one of two key domains necessary for VHL function. This gene may contribute to the regulation of oxygen homeostasis and neovascularization during placenta development. This gene is intronless, and can also be interpreted as a retrotransposed pseudogene of the VHL locus located on chromosome 3. However, the protein is represented in this RefSeq due to evidence in PMID:14757845 that strongly suggests it is translated. The same publication also indicates that this protein binds HIF alpha but fails to recruit the E3 ubiquitin ligase complex, and it therefore functions as a dominant-negative VHL protein and a protector of HIF alpha.
Alias Symbols: VHLP, VLP
Protein Interaction Partner: RBPMS, DAZAP2, HIF1A,
Protein Size: 139

Poids moléculaire: 15 kDa

ID gène: 391104

NCBI Accession: NM_001004319, NP_001004319

UniProt: Q6RSH7