SPTA1 anticorps (N-Term)

N° du produit ABIN2792075

Cet anticorps anti-SPTA1 Polyclonal Lapin (ABIN2792075) détecte spécifiquement SPTA1 dans WB. L’anticorps est réactif avec des échantillons de Humain, Souris, Rat, Boeuf (Vache), Cobaye, Cheval et Lapin.

Aperçu rapide pour SPTA1 anticorps (N-Term) (ABIN2792075)

Antigène: SPTA1 (Spectrin alpha 1, Erythrocytic (SPTA1))

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Cobaye, Cheval, Lapin

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SPTA1 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-SPTA1 anticorps

Épitope: N-Term

Séquence: DELSGWMNEK TAAINADELP TDVAGGEVLL DRHQQHKHEI DSYDDRFQSA

Homologie: Cow: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 92%, Rat: 100%

Attributs du produit: This is a rabbit polyclonal antibody against SPTA1. It was validated on Western Blot.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N-terminal region of Human SPTA1

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeat freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur SPTA1

Antigène: SPTA1 (Spectrin alpha 1, Erythrocytic (SPTA1))

Autre désignation: SPTA1

Sujet: Spectrin is an actin crosslinking and molecular scaffold protein that links the plasma membrane to the actin cytoskeleton, and functions in the determination of cell shape, arrangement of transmembrane proteins, and organization of organelles. It is a tetramer made up of alpha-beta dimers linked in a head-to-head arrangement. This gene is one member of a family of alpha-spectrin genes. The encoded protein is primarily composed of 22 spectrin repeats which are involved in dimer formation. It forms weaker tetramer interactions than non-erythrocytic alpha spectrin, which may increase the plasma membrane elasticity and deformability of red blood cells. Mutations in this gene result in a variety of hereditary red blood cell disorders, including elliptocytosis type 2, pyropoikilocytosis, and spherocytic hemolytic anemia.
Alias Symbols: EL2, HPP, HS3, SPH3, SPTA
Protein Interaction Partner: ANK1, PTPRO, UBC, YWHAQ, MYBL2, PTPN22, BTK, UBASH3B, SHC1, CBL, FASLG, NCOA3, ENAH, EVL, SPTBN2, ABI1, VASP, PLEC, SLC9A2, FANCC, SPTB, ADD1, ACTA1, ABL1, EZR, FANCA, ERCC4,
Protein Size: 2419

Poids moléculaire: 266 kDa

ID gène: 6708

NCBI Accession: NM_003126, NP_003117

UniProt: P02549

Pathways: Regulation of Actin Filament Polymerization