PRDM1 anticorps (Middle Region)

N° du produit ABIN2792524

Cité dans 1 publication. Cet anticorps anti-PRDM1 Polyclonal Lapin (ABIN2792524) détecte spécifiquement PRDM1 dans WB et IHC. L’anticorps est réactif avec des échantillons de Humain, Souris, Rat, Chien, Porc, Boeuf (Vache), Cheval, Lapin et Cobaye.

Aperçu rapide pour PRDM1 anticorps (Middle Region) (ABIN2792524)

Antigène: PRDM1 (PR Domain Containing 1, with ZNF Domain (PRDM1))

Reactivité: Humain, Souris, Rat, Chien, Porc, Boeuf (Vache), Cheval, Lapin, Cobaye

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PRDM1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Détail du produit anti-PRDM1 anticorps

Épitope: Middle Region

Fonction: PRDM1 Antibody - middle region

Séquence: VEDDISVISV VEKEILAVVR KEKEETGLKV SLQRNMGNGL LSSGCSLYES

Réactivité croisée: Boeuf (Vache), Humain, Souris, Rat (Rattus)

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 84%, Horse: 100%, Human: 100%, Mouse: 92%, Pig: 100%, Rabbit: 92%, Rat: 92%

Attributs du produit: This is a rabbit polyclonal antibody against PRDM1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human PRDM1

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: prevent freeze-thaw cycles

Stock: 4 °C,-20 °C

Stockage commentaire: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-PRDM1 (ABIN2792524)

Arulanandam, Batenchuk, Angarita, Ottolino-Perry, Cousineau, Mottashed, Burgess, Falls, De Silva, Tsang, Howe, Bourgeois-Daigneault, Conrad, Daneshmand, Breitbach, Kirn, Raptis, Sad, Atkins, Huh et al.: "VEGF-Mediated Induction of PRD1-BF1/Blimp1 Expression Sensitizes Tumor Vasculature to Oncolytic Virus Infection. ..." dans: Cancer cell, Vol. 28, Issue 2, pp. 210-24, (2015) (PubMed).

Détails sur PRDM1

Antigène: PRDM1 (PR Domain Containing 1, with ZNF Domain (PRDM1))

Autre désignation: PRDM1

Sujet:

Background Information: PRDM1 is a protein that acts as a repressor of beta-interferon gene expression. The protein binds specifically to the PRDI (positive regulatory domain I element) of the beta-IFN gene promoter. Transcription of this gene increases upon virus induction. Two alternatively spliced transcript variants that encode different isoforms have been reported. This gene encodes a protein that acts as a repressor of beta-interferon gene expression. The protein binds specifically to the PRDI (positive regulatory domain I element) of the beta-IFN gene promoter. Transcription of this gene increases upon virus induction. Two alternatively spliced transcript variants that encode different isoforms have been reported.

Gene Name: PR domain containing 1, with ZNF domain

Alternative Symbols: BLIMP1, PRDI-BF1

Protein Name: PR domain zinc finger protein 1

Poids moléculaire: 92 kDa

ID gène: 639

NCBI Accession: NP_878911

UniProt: Q86WM7

Pathways: Regulation of Muscle Cell Differentiation