NFKBIL2 anticorps (Middle Region)

N° du produit ABIN2792627

Cet anticorps Lapin Polyclonal détecte spécifiquement NFKBIL2 dans WB. Il présente une réactivité envers Humain, Souris, Rat et Chien et a été mentionné dans 1 publication.

Aperçu rapide pour NFKBIL2 anticorps (Middle Region) (ABIN2792627)

Antigène: NFKBIL2 (Tonsoku-Like, DNA Repair Protein (NFKBIL2))

Reactivité: Humain, Souris, Rat, Chien

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NFKBIL2 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-NFKBIL2 anticorps

Épitope: Middle Region

Séquence: RAIIHVSLAT TLGDMKDHHG AVRHYEEELR LRSGNVLEEA KTWLNIALSR

Réactivité croisée: Chien, Humain, Souris, Rat (Rattus)

Homologie: Dog: 84%, Human: 100%, Mouse: 83%, Rat: 83%

Attributs du produit: This is a rabbit polyclonal antibody against NFKBIL2. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human NFKBIL2

Information d'application

Indications d'application: WB Suggested Anti-NFKBIL2 Antibody Titration: 0.2-1 µg/mL
ELISA Titer: 1:62500
Positive Control: 293T cell lysate.
Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 1219 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-NFKBIL2 (ABIN2792627)

Ewing, Chu, Elisma, Li, Taylor, Climie, McBroom-Cerajewski, Robinson, OConnor, Li, Taylor, Dharsee, Ho, Heilbut, Moore, Zhang, Ornatsky, Bukhman, Ethier, Sheng, Vasilescu, Abu-Farha, Lambert, Duewel et al.: "Large-scale mapping of human protein-protein interactions by mass spectrometry. ..." dans: Molecular systems biology, Vol. 3, pp. 89, (2007) (PubMed).

Détails sur NFKBIL2

Antigène: NFKBIL2 (Tonsoku-Like, DNA Repair Protein (NFKBIL2))

Autre désignation: NFKBIL2 / IKBR

Sujet: NFKBIL2 is thought to be a negative regulator of NF-kappa-B mediated transcription. It may bind NF-kappa-B complexes and trap them in the cytoplasm, preventing them from entering the nucleus and interacting with the DNA. Phosphorylation of this protein targets it for degradation by the ubiquitination pathway, which frees the NF-kappa-B complexes to enter the nucleus.The protein encoded by this gene is thought to be a negative regulator of NF-kappa-B mediated transcription. The encoded protein may bind NF-kappa-B complexes and trap them in the cytoplasm, preventing them from entering the nucleus and interacting with the DNA. Phosphorylation of this protein targets it for degradation by the ubiquitination pathway, which frees the NF-kappa-B complexes to enter the nucleus.
Alias Symbols: FLJ40087, IKBR, NFKBIL2
Protein Interaction Partner: HIST3H3, MCM6, MCM2, MMS22L, ASF1B, ASF1A, UBC, MYC, MAU2, SLC25A5, SUPT16H, SUGT1, AIFM1, HIST1H2BL, XRCC5, SSRP1, SLC25A3, TONSL, MCM4, HIST1H2AE, HIST1H1B, HIST1H1C, XRCC6, GSK3B, MCM7, MCM5, MCM3, EWSR1,
Protein Size: 1219

Poids moléculaire: 133 kDa

ID gène: 4796

NCBI Accession: NM_013432, NP_038460

UniProt: Q96HA7

Pathways: Maintenance of Protein Location