EN1 anticorps (C-Term)

N° du produit ABIN2792656

Détail du produit anti-EN1 anticorps

Antigène: EN1 (Engrailed Homeobox 1 (EN1))

Épitope: C-Term

Reactivité: Cobaye, Lapin

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp EN1 est non-conjugé

Application: Western Blotting (WB)

Séquence: LMGSANGGPV VKTDSQQPLV WPAWVYCTRY SDRPSSGPRT RKLKKKKNEK

Réactivité croisée: Poulet, Humain, Souris

Homologie: Guinea Pig: 93%, Rabbit: 86%

Attributs du produit: This is a rabbit polyclonal antibody against EN1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the C terminal region of human EN1

Information d'application

Indications d'application: WB Suggested Anti-EN1 Antibody Titration: 0.2-1 µg/mL
ELISA Titer: 1:312500
Positive Control: HepG2 cell lysate.
Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 392 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-EN1 (ABIN2792656)

Beltran, Graves, Blancafort: "Novel role of Engrailed 1 as a prosurvival transcription factor in basal-like breast cancer and engineering of interference peptides block its oncogenic function." dans: Oncogene, Vol. 33, Issue 39, pp. 4767-77, (2014) (PubMed).

Détails sur EN1

Antigène: EN1 (Engrailed Homeobox 1 (EN1))

Autre désignation: Engrailed-1 / EN1 (EN1 Produits)

Synonymes: anticorps EN1, anticorps En-1, anticorps Mo-en.1, anticorps ENG-1, anticorps en-1, anticorps en1, anticorps eng1, anticorps zgc:100771, anticorps en1-A, anticorps engrailed-1, anticorps xen1, anticorps Gg-En-1, anticorps en-3, anticorps engrailed, anticorps engrailed homeobox 1, anticorps engrailed 1, anticorps engrailed homeobox 1a, anticorps engrailed homeobox 1 S homeolog, anticorps EN1, anticorps En1, anticorps en1a, anticorps en1.S

Sujet: Homeobox-containing genes are thought to have a role in controlling development. In Drosophila, the 'engrailed' (en) gene plays an important role during development in segmentation, where it is required for the formation of posterior compartments. Different mutations in the mouse homologs, En1 and En2, produced different developmental defects that frequently are lethal. The human engrailed homologs 1 and 2 encode homeodomain-containing proteins and have been implicated in the control of pattern formation during development of the central nervous system.Homeobox-containing genes are thought to have a role in controlling development. In Drosophila, the 'engrailed' (en) gene plays an important role during development in segmentation, where it is required for the formation of posterior compartments. Different mutations in the mouse homologs, En1 and En2, produced different developmental defects that frequently are lethal. The human engrailed homologs 1 and 2 encode homeodomain-containing proteins and have been implicated in the control of pattern formation during development of the central nervous system. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: -
Protein Interaction Partner: TLE1, PAX6, JUN,
Protein Size: 392

Poids moléculaire: 40 kDa

ID gène: 2019

NCBI Accession: NM_001426, NP_001417

UniProt: Q05925

Pathways: Dopaminergic Neurogenesis