Caveolin-1 anticorps (N-Term)

N° du produit ABIN2792696

L’anticorps Lapin Polyclonal anti-Caveolin-1 a été validé pour WB. Il convient pour détecter Caveolin-1 dans des échantillons de Humain, Rat, Souris, Chien, Porc, Boeuf (Vache), Lapin, Mouton et Cheval.

Aperçu rapide pour Caveolin-1 anticorps (N-Term) (ABIN2792696)

Antigène: Caveolin-1 (CAV1) (Caveolin 1, Caveolae Protein, 22kDa (CAV1))

Reactivité: Humain, Rat, Souris, Chien, Porc, Boeuf (Vache), Lapin, Mouton, Cheval

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Caveolin-1 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-Caveolin-1 anticorps

Épitope: N-Term

Séquence: SGGKYVDSEG HLYTVPIREQ GNIYKPNNKA MADELSEKQV YDAHTKEIDL

Réactivité croisée: Humain, Souris, Rat (Rattus)

Homologie: Cow: 80%, Dog: 86%, Horse: 86%, Human: 100%, Mouse: 86%, Pig: 80%, Rabbit: 86%, Rat: 86%, Sheep: 80%

Attributs du produit: This is a rabbit polyclonal antibody against CAV1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human CAV1

Information d'application

Indications d'application: WB Suggested Anti-CAV1 Antibody Titration: 0.2-1 µg/mL
ELISA Titer: 1:62500
Positive Control: Human Liver.
Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 178 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur Caveolin-1

Antigène: Caveolin-1 (CAV1) (Caveolin 1, Caveolae Protein, 22kDa (CAV1))

Autre désignation: Caveolin-1

Sujet: The scaffolding protein CAV1 is the main component of the caveolae plasma membranes found in most cell types. The protein links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. The gene is a tumor suppressor gene candidate and a negative regulator of the Ras-p42/44 MAP kinase cascade. CAV1 and CAV2 are located next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex. By using alternative initiation codons in the same reading frame, two isoforms (alpha and beta) are encoded by a single transcript from this gene.The scaffolding protein encoded by this gene is the main component of the caveolae plasma membranes found in most cell types. The protein links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. The gene is a tumor suppressor gene candidate and a negative regulator of the Ras-p42/44 MAP kinase cascade. CAV1 and CAV2 are located next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex. By using alternative initiation codons in the same reading frame, two isoforms (alpha and beta) are encoded by a single transcript from this gene. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: CAV, MSTP085, VIP21, CGL3, BSCL3
Protein Interaction Partner: TFRC, ABCC1, UBC, RPA3, ATG5, ATG12, RPA2, RPA1, PTGIS, EGFR, VCP, UFD1L, PTGS2, PTGS1, ESR1, DERL1, VIMP, ATP4A, CAV2, GLIPR2, KDR, PROCR, F2R, BID, NOS3, HSP90AA1, FAS, ACTB, MALL, NF1, LRP6, KCNMA1, BMPR2, BMPR1A, AXIN1, PPP2CA, MCL1, ITPR3, ID1, TENC1
Protein Size: 178

Poids moléculaire: 20 kDa

ID gène: 857

NCBI Accession: NM_001753, NP_001744

UniProt: Q03135

Pathways: Maintenance of Protein Location, Signaling Events mediated by VEGFR1 and VEGFR2, Negative Regulation of Transporter Activity, VEGFR1 Specific Signals