Nucleobindin 1 anticorps (C-Term)

N° du produit ABIN2792698

Cet anticorps Lapin Polyclonal détecte spécifiquement Nucleobindin 1 dans WB. Il présente une réactivité envers Humain et a été mentionné dans 6+ publications.

Aperçu rapide pour Nucleobindin 1 anticorps (C-Term) (ABIN2792698)

Antigène: Nucleobindin 1 (NUCB1)

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Nucleobindin 1 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-Nucleobindin 1 anticorps

Épitope: C-Term

Séquence: PAAHPEGQLK FHPDTDDVPV PAPAGDQKEV DTSEKKLLER LPEVEVPQHL

Réactivité croisée: Humain

Homologie: Human: 100%

Attributs du produit: This is a rabbit polyclonal antibody against NUCB1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the C terminal region of human NUCB1

Information d'application

Indications d'application: WB Suggested Anti-NUCB1 Antibody Titration: 0.2-1 µg/mL
ELISA Titer: 1:1562500
Positive Control: HepG2 cell lysate.
Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 461 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-Nucleobindin 1 (ABIN2792698)

Bonito-Oliva, Barbash, Sakmar, Graham: "Nucleobindin 1 binds to multiple types of pre-fibrillar amyloid and inhibits fibrillization." dans: Scientific reports, Vol. 7, pp. 42880, (2017) (PubMed).

Larkin, Ribeiro, Lavoie: "Topology and membrane anchoring of the lysosomal storage disease-related protein CLN5." dans: Human mutation, Vol. 34, Issue 12, pp. 1688-97, (2013) (PubMed).

Lin, Fischer, Lavoie, Huang, Farquhar: "Calnuc plays a role in dynamic distribution of Galphai but not Gbeta subunits and modulates ACTH secretion in AtT-20 neuroendocrine secretory cells." dans: Molecular neurodegeneration, Vol. 4, pp. 15, (2009) (PubMed).

Valencia, Cotten, Duan, Liu: "Modulation of nucleobindin-1 and nucleobindin-2 by caspases." dans: FEBS letters, Vol. 582, Issue 2, pp. 286-90, (2008) (PubMed).

Sugeno, Takeda, Hasegawa, Kobayashi, Kikuchi, Mori, Wakabayashi, Itoyama: "Serine 129 phosphorylation of alpha-synuclein induces unfolded protein response-mediated cell death." dans: The Journal of biological chemistry, Vol. 283, Issue 34, pp. 23179-88, (2008) (PubMed).

Lin, Li, Zhang, Huang, Tong, Farquhar, Xu: "Calnuc binds to Alzheimer's beta-amyloid precursor protein and affects its biogenesis." dans: Journal of neurochemistry, Vol. 100, Issue 6, pp. 1505-14, (2007) (PubMed).

Détails sur Nucleobindin 1

Antigène: Nucleobindin 1 (NUCB1)

Autre désignation: Nucleobindin-1

Sujet: Nucleobindin, also known as calnuc, participates in Ca2+ storage in the Golgi, as well as in other biological processes that involve DNA-binding and protein-protein interactions.
Alias Symbols: NUC, CALNUC
Protein Interaction Partner: REL, UBC, MDM2, CTPS2, RAD23B, PRKDC, METTL1, GTF2I, CBS, XPNPEP1, WARS, PTGS2, XPO1, SET, RBL1, MYC, HIVEP1, GNAS, GNAI3, GNAI1, KLC4, PTGS1, NDN, GNAI2, GNAO1, GNAZ,
Protein Size: 461

Poids moléculaire: 54 kDa

ID gène: 4924

NCBI Accession: NM_006184, NP_006175

UniProt: Q02818