MECP2 anticorps (pSer421)

N° du produit ABIN2794307

L’anticorps Lapin Polyclonal anti-MECP2 a été validé pour DB. Il convient pour détecter MECP2 dans des échantillons de Humain.

Aperçu rapide pour MECP2 anticorps (pSer421) (ABIN2794307)

Antigène: MECP2 (Methyl CpG Binding Protein 2 (MECP2))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MECP2 est non-conjugé

Application: Dot Blot (DB)

Détail du produit anti-MECP2 anticorps

Épitope: pSer421

Fonction: Rabbit Anti-Human Phospho-MeCP2(S421) Antibody

Immunogène: This MeCP2 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S421 of human MeCP2.

Isotype: Ig Fraction

Information d'application

Indications d'application: Dot Blot
Recommended Dilutions
DB: 1:500
Dot blot analysis of anti-Phospho-MeCP2-S421 Pab on nitrocellulose membrane. 50 ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.5 μg per ml.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.350 mg/mL

Stock: 4 °C,-20 °C

Stockage commentaire: 2-8°C (short-term), -20°C (long-term)

Détails sur MECP2

Antigène: MECP2 (Methyl CpG Binding Protein 2 (MECP2))

Autre désignation: MeCP2

Sujet:

Target Description: DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. In contrast to other MBD family members, MECP2 is X-linked and subject to X inactivation. MECP2 is dispensible in stem cells, but is essential for embryonic development. MECP2 gene mutations are the cause of some cases of Rett syndrome, a progressive neurologic developmental disorder and one of the most common causes of mental retardation in females.

Gene Symbol: MECP2

Poids moléculaire: 52441 Da

ID gène: 4204

UniProt: P51608

Pathways: Inositol Metabolic Process, Chromatin Binding, Synaptic Membrane