SIGLEC11 anticorps (C-Term)

N° du produit ABIN2799004

Détail du produit anti-SIGLEC11 anticorps

Antigène: SIGLEC11 (Sialic Acid Binding Ig-Like Lectin 11 (SIGLEC11))

Épitope: AA 631-662, C-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SIGLEC11 est non-conjugé

Application: Immunohistochemistry (IHC), Western Blotting (WB)

Fonction: Rabbit Anti-Human SIGLEC11 (C-term) Antibody

Immunogène: This SIGLEC11 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 631-662 amino acids from the C-terminal region of human SIGLEC11.

Isotype: Ig Fraction

Information d'application

Indications d'application: Western Blot, Immunohistochemistry
Recommended Dilutions
WB: 1:1000, IHC: 1:10-50SIGLEC11 Antibody for immunohistochemistry. Clinical relevance has not been evaluated.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.310 mg/mL

Stock: 4 °C,-20 °C

Stockage commentaire: 2-8°C (short-term), -20°C (long-term)

Détails sur SIGLEC11

Antigène: SIGLEC11 (Sialic Acid Binding Ig-Like Lectin 11 (SIGLEC11))

Autre désignation: SIGLEC11 (SIGLEC11 Produits)

Synonymes: anticorps sialic acid binding Ig like lectin 11, anticorps SIGLEC11

Sujet:

Target Description: SIGLECs are members of the immunoglobulin superfamily that are expressed on the cell surface. Most SIGLECs have one or more cytoplasmic immune receptor tyrosine-based inhibitory motifs (ITIM). SIGLECs are typically expressed on cells of the innate immune system, with the exception of the B-cell expressed SIGLEC6. Sequence analysis predicted that the 697-amino acid SIGLEC10 protein contains a signal peptide, an N-terminal V-set Ig-like domain and four C2-set Ig-like domains, five potential N-linked glycosylation sites, a transmembrane region, and a 126-residue cytoplasmic tail with 3 putative ITIMs. Northern blot analysis detected a major 3.0-kb SIGLEC10 transcript, with highest levels in spleen, lymph node, blood leukocytes, and appendix. Little or no expression was observed in pancreas, thyroid, and testis. Flow cytometric analysis demonstrated eosinophil-specific expression of SIGLEC10, but at a lower level than that of SIGLEC8. Expression was also detected on monocytes and a CD16-positive/CD56-negative natural killer-like lymphocyte population. After sialidase treatment, which is necessary for unmasking the sialic acid-binding site on SIGLECs interacting with cell surface sialic acids, cells expressing SIGLEC10 bound to red blood cells. Immunoprecipitation analysis indicated expression of a 100- to 120-kD monomeric protein, higher than the predicted molecular mass, suggesting that SIGLEC10 is glycosylated.

Gene Symbol: SIGLEC11

Poids moléculaire: 75795 Da

ID gène: 114132

UniProt: Q96RL6