LLGL1+2 (pSer650), (pSer654) anticorps

N° du produit ABIN388990

Cet anticorps Lapin Polyclonal détecte spécifiquement LLGL1+2 dans WB. Il présente une réactivité avec des échantillons de Humain.Il a été cité dans 1 publication.

Aperçu rapide pour LLGL1+2 (pSer650), (pSer654) anticorps (ABIN388990)

Antigène: LLGL1+2

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Inconjugué

Application: Western Blotting (WB)

Clone: RB7629-RB7630

Détail du produit

Épitope: pSer650, pSer654

Homologie: Cow (Bovine),Mouse (Murine),Rat (Rattus)

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This LLGL1/2 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S645/S649 of human LLGL1/2.

Isotype: Ig Fraction

Information d'application

Indications d'application: Suggested dilutions:
WB = 1:1000
Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: PBS with 0.09 % (W/V) sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Conseil sur la manipulation: Avoid freeze-thaw cycles.

Stock: 4 °C/-20 °C

Stockage commentaire: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots.

Date de péremption: 6 months

Référence

Solinet, Akpovi, Garcia, Barry, Vitale: "Myosin IIB deficiency in embryonic fibroblasts affects regulators and core members of the par polarity complex." dans: Histochemistry and cell biology, Vol. 136, Issue 3, pp. 245-66, (2011) (PubMed).

Détail du antigène

Antigène: LLGL1+2

Sujet: Function
Part of a complex with GPSM2/LGN, PRKCI/aPKC and PARD6B/Par-6, which may ensure the correct organization and orientation of bipolar spindles for normal cell division. This complex plays roles in the initial phase of the establishment of epithelial cell polarity.

Cellular Location
Cytoplasm. Note=Localized in the perinuclear structure and faintly at the cell-cell contacts sites in the interphase. Localized at the cell periphery during metaphase Cortical localization in mitotic cells. Found in the lateral region of polarized epithelial cells

Synonyms: Lethal(2) giant larvae protein homolog 2, HGL, LLGL2, Lethal(2) giant larvae protein homolog 1, LLGL, Human homolog to the D-lgl gene, Hugl-1, DLG4, LLGL1, HUGL

Poids moléculaire: 115042 Da

ID gène: 3993

UniProt: Q6P1M3