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IL1RL1 anticorps (FITC)

IL1RL1 Reactivité: Humain FACS Hôte: Souris Monoclonal 2A5 FITC
N° du produit ABIN2853578
  • Antigène Voir toutes IL1RL1 Anticorps
    IL1RL1 (Interleukin 1 Receptor-Like 1 (IL1RL1))
    Reactivité
    • 60
    • 28
    • 21
    • 6
    • 4
    • 4
    • 1
    Humain
    Hôte
    • 49
    • 11
    • 1
    • 1
    Souris
    Clonalité
    • 48
    • 14
    Monoclonal
    Conjugué
    • 32
    • 5
    • 5
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp IL1RL1 est conjugé à/à la FITC
    Application
    • 31
    • 30
    • 17
    • 8
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Flow Cytometry (FACS)
    Specificité
    This antibody reacts with ST2.
    Réactivité croisée (Details)
    Species reactivity (tested):Human
    Purification
    Protein A agarose
    Immunogène
    Secreted form of ST2 protein which were purified from culture supernatant of COS7 transfectant cells
    Clone
    2A5
    Isotype
    IgG1
    Top Product
    Discover our top product IL1RL1 Anticorps primaire
  • Indications d'application
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Buffer
    50 tests in a 100 μL volume of PBS, 0.09 % NaN3, 1 % BSA
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C
    Stockage commentaire
    Store at 2 - 8 °C.
  • Antigène
    IL1RL1 (Interleukin 1 Receptor-Like 1 (IL1RL1))
    Autre désignation
    IL1RL1 / ST2 (IL1RL1 Produits)
    Synonymes
    anticorps DER4, anticorps Fit-1, anticorps Ly84, anticorps ST2L, anticorps St2, anticorps St2-rs1, anticorps T1, anticorps T1/ST2, anticorps FIT-1, anticorps IL33R, anticorps ST2, anticorps ST2V, anticorps FIT1, anticorps interleukin 1 receptor-like 1, anticorps interleukin 1 receptor like 1, anticorps Il1rl1, anticorps IL1RL1
    Sujet
    The ST2 gene, also known as T1, Fit1, or DER4, was originally identified as a responsive gene that was highly induced by stimulation of various proliferation-inducing agents including serum, PDGF (platelet-derived growth factor), FGF (fibroblast growth factor), or lysophosphatidic acid in murine fibroblasts. Three distinct forms of gene products have been reported and named ST2, ST2V, and ST2L. ST2 is a soluble secreted form of a 37 kDa protein, which lacks an intracellular domain, whereas ST2L is a transmembrane form of a 62 kDa protein (the glycosylated forms of ST2 and ST2L are about 57 and 80 kDa, respectively). This ST2L protein is very similar to IL-1R (interleukin-1 receptor) type I and II in structure, thus it is considered a member of the IL-1R family. ST2V, which is another novel variant form of human ST2, has been identified recently. ST2 proteins are expressed in several types of human cells, including hematopoietic cells in various stages of differentiation, a population of the peripheral blood mononuclear cells from healthy individuals, glioblastoma and astrocytoma cell lines, and colon cancer cells in addition to fibroblast cell lines. Thus ST2 proteins are considered to have some roles in regulating cell growth or proliferation. On the other hand, definitive functions of ST2 proteins and their ligand molecule(s) which bind to ST2 proteins have remained unclear, though it has been reported that IL-1a, ß, RA (receptor antagonist) do not bind to ST2 proteins in spite of their structural similarity to IL-1R. This indicates that the ST2L protein is functionally independent from IL-1R. Furthermore, several studies have shown that ST2L is expressed on the cell surface of Th2 cells but not on Th1 cells, indicating the possibility that the ST2L protein participates not only in the regulation of cell growth or proliferation, but also in the immune system including differentiation of T cells or immunological response via helper T cells. From these observations, ST2 proteins are considered to be important proteins that participate in various physiological phenomenons, thus further analysis is required to understand its physiological functions.Synonyms: DER4, FIT-1, Homolog of mouse growth stimulation-expressed, Interleukin-1 receptor-like 1, MGC32623
    ID gène
    9173
    NCBI Accession
    NP_003847
    UniProt
    Q01638
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