SNAIL anticorps

N° du produit ABIN2854294

Cet anticorps Lapin Polyclonal détecte spécifiquement SNAIL dans WB, IF, IHC (p) et ICC. Il présente une réactivité envers Humain et a été mentionné dans 4+ publications.

Aperçu rapide pour SNAIL anticorps (ABIN2854294)

Antigène: SNAIL (SNAI1)

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SNAIL est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC)

Détail du produit anti-SNAIL anticorps

Réactivité croisée: Humain, Souris, Rat

Attributs du produit: Rabbit Polyclonal antibody to SNAI1 (snail family zinc finger 1)
SNAI1 antibody

Purification: Purified by antigen-affinity chromatography.

Immunogène: Recombinant protein encompassing a sequence within the center region of human SNAI1. The exact sequence is proprietary.

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Commentaires:

Positive Control: U87-MG , SK-N-SH , IMR32 , SK-N-AS , HeLa (starvation for 16 hr 20 ng/ml TGF-beta and 300 ng/ml EGF treatment for 30 min) , SNAI1-transfected 293T

Validation: Comparison, Orthogonal, Overexpression

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1.54 mg/mL

Buffer: 1XPBS ( pH 7), 20 % Glycerol, 0.025 % ProClin 300

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Références pour anticorps anti-SNAIL (ABIN2854294)

Chung, Lee, Hu, Chou, Lin, Shih: "NKX6.1 Represses Tumorigenesis, Metastasis, and Chemoresistance in Colorectal Cancer." dans: International journal of molecular sciences, Vol. 21, Issue 14, (2020) (PubMed).

Roth, Jayaratna, Sundi, Cheng, Melquist, Choi, Porten, Nitti, Navai, Wszolek, Guo, Czerniak, McConkey, Dinney: "Employing an orthotopic model to study the role of epithelial-mesenchymal transition in bladder cancer metastasis." dans: Oncotarget, Vol. 8, Issue 21, pp. 34205-34222, (2018) (PubMed).

Li, Yu, Huang, Su, Hsiao, Chang, Yu, Lin: "NKX6.1 functions as a metastatic suppressor through epigenetic regulation of the epithelial-mesenchymal transition." dans: Oncogene, Vol. 35, Issue 17, pp. 2266-78, (2017) (PubMed).

Liu, Weng, Lin, Tang, Chen, Liang, Ku, Lin: "Aqueous extract of Polygonum bistorta modulates proteostasis by ROS-induced ER stress in human hepatoma cells." dans: Scientific reports, Vol. 7, pp. 41437, (2017) (PubMed).

Détails sur SNAIL

Antigène: SNAIL (SNAI1)

Autre désignation: snail family transcriptional repressor 1

Sujet: The Drosophila embryonic protein snail is a zinc finger transcriptional repressor which downregulates the expression of ectodermal genes within the mesoderm. The nuclear protein encoded by this gene is structurally similar to the Drosophila snail protein, and is also thought to be critical for mesoderm formation in the developing embryo. At least two variants of a similar processed pseudogene have been found on chromosome 2.

Cellular Localization: Nucleus

Poids moléculaire: 29 kDa

ID gène: 6615

UniProt: O95863

Pathways: Negative Regulation of intrinsic apoptotic Signaling