FAP anticorps

N° du produit ABIN2854402

Cet anticorps Lapin Polyclonal détecte spécifiquement FAP dans WB. Il présente une réactivité envers Humain et a été mentionné dans 1 publication.

Aperçu rapide pour FAP anticorps (ABIN2854402)

Antigène: FAP (Fibroblast Activation Protein, alpha (FAP))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FAP est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-FAP anticorps

Réactivité croisée: Humain

Attributs du produit: Rabbit polyclonal antibody to FAP (fibroblast activation protein, alpha)
FAP antibody [N1N3]

Purification: Purified by antigen-affinity chromatography.

Immunogène: Recombinant protein encompassing a sequence within the center region of human FAP. The exact sequence is proprietary.

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:3000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Commentaires:

Positive Control: HepG2 , Molt-4

Validation: Orthogonal

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.58 mg/mL

Buffer: 0.1M Tris-Glycine ( pH 7), 10 % Glycerol, 0.01 % Thimerosal

Agent conservateur: Thimerosal (Merthiolate)

Précaution d'utilisation: This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Références pour anticorps anti-FAP (ABIN2854402)

Wolczyk, Zaremba-Czogalla, Hryniewicz-Jankowska, Tabola, Grabowski, Sikorski, Augoff: "TNF-α promotes breast cancer cell migration and enhances the concentration of membrane-associated proteases in lipid rafts." dans: Cellular oncology (Dordrecht), Vol. 39, Issue 4, pp. 353-63, (2017) (PubMed).

Détails sur FAP

Antigène: FAP (Fibroblast Activation Protein, alpha (FAP))

Autre désignation: fibroblast activation protein alpha

Sujet: The protein encoded by this gene is a homodimeric integral membrane gelatinase belonging to the serine protease family. It is selectively expressed in reactive stromal fibroblasts of epithelial cancers, granulation tissue of healing wounds, and malignant cells of bone and soft tissue sarcomas. This protein is thought to be involved in the control of fibroblast growth or epithelial-mesenchymal interactions during development, tissue repair, and epithelial carcinogenesis.

Cellular Localization: Cell membrane, Single-pass type II membrane protein , Cell projection , lamellipodium membrane, Single-pass type II membrane protein , invadopodium membrane, Single-pass type II membrane protein

Poids moléculaire: 88 kDa

ID gène: 2191

UniProt: Q12884

Pathways: Tube Formation