CRYAB anticorps

N° du produit ABIN2854419

Détail du produit anti-CRYAB anticorps

Antigène: CRYAB (Crystallin, alpha B (CRYAB))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CRYAB est non-conjugé

Application: Western Blotting (WB)

Réactivité croisée: Souris, Rat

Attributs du produit: Rabbit polyclonal antibody to crystallin alpha B (crystallin, alpha B)
crystallin alpha B antibody [N1C3]

Purification: Purified by antigen-affinity chromatography.

Immunogène: Recombinant protein encompassing a sequence within the center region of human alpha B Crystallin. The exact sequence is proprietary.

Isotype: IgG

Information d'application

Indications d'application: WB: 1:5000-1:50000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Commentaires:

Positive Control: mouse eye

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.98 mg/mL

Buffer: 0.1M Tris-Glycine ( pH 7), 20 % Glycerol, 0.01 % Thimerosal

Agent conservateur: Thimerosal (Merthiolate)

Précaution d'utilisation: This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Détails sur CRYAB

Antigène: CRYAB (Crystallin, alpha B (CRYAB))

Autre désignation: crystallin alpha B (CRYAB Produits)

Synonymes: anticorps CMD1II, anticorps CRYA2, anticorps CTPP2, anticorps CTRCT16, anticorps HSPB5, anticorps MFM2, anticorps Crya-2, anticorps Crya2, anticorps HspB5, anticorps AACRYA, anticorps CRYAB, anticorps cryab, anticorps cryab2, anticorps wu:fe37f08, anticorps zgc:91937, anticorps crystallin alpha B, anticorps crystallin, alpha B, anticorps hypothetical protein, anticorps crystallin, alpha B, a, anticorps crystallin, alpha B, b, anticorps CRYAB, anticorps Cryab, anticorps ZK1128.7, anticorps cryaba, anticorps cryabb

Sujet: Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families, beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Alpha crystallins are composed of two gene products: alpha-A and alpha-B, for acidic and basic, respectively. Alpha crystallins can be induced by heat shock and are members of the small heat shock protein (sHSP also known as the HSP20) family. They act as molecular chaperones although they do not renature proteins and release them in the fashion of a true chaperone, instead they hold them in large soluble aggregates. Post-translational modifications decrease the ability to chaperone. These heterogeneous aggregates consist of 30-40 subunits, the alpha-A and alpha-B subunits have a 3:1 ratio, respectively. Two additional functions of alpha crystallins are an autokinase activity and participation in the intracellular architecture. Alpha-A and alpha-B gene products are differentially expressed, alpha-A is preferentially restricted to the lens and alpha-B is expressed widely in many tissues and organs. Elevated expression of alpha-B crystallin occurs in many neurological diseases, a missense mutation cosegregated in a family with a desmin-related myopathy.

Poids moléculaire: 20 kDa

ID gène: 1410

UniProt: P02511