ADAMTSL2 anticorps (C-Term)

N° du produit ABIN2855279

L’anticorps Lapin Polyclonal anti-ADAMTSL2 a été validé pour WB et IHC (p). Il convient pour détecter ADAMTSL2 dans des échantillons de Humain. Il y a 2+ publications disponibles.

Aperçu rapide pour ADAMTSL2 anticorps (C-Term) (ABIN2855279)

Antigène: ADAMTSL2 (ADAMTS-Like 2 (ADAMTSL2))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ADAMTSL2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-ADAMTSL2 anticorps

Épitope: C-Term

Réactivité croisée: Humain, Souris

Attributs du produit: Rabbit Polyclonal antibody to ADAMTSL2 (ADAMTS-like 2)
ADAMTSL2 antibody [C3], C-term

Purification: Purified by antigen-affinity chromatography.

Immunogène: Recombinant protein encompassing a sequence within the C-terminus region of human ADAMTSL2. The exact sequence is proprietary.

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:3000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Commentaires:

Positive Control: H1299

Validation: Orthogonal

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: 0.1M Tris-Glycine ( pH 7), 10 % Glycerol, 0.01 % Thimerosal

Agent conservateur: Thimerosal (Merthiolate)

Précaution d'utilisation: This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Références pour anticorps anti-ADAMTSL2 (ABIN2855279)

Piccolo, Sabatino, Mithbaokar, Polishchuck, Law, Magraner-Pardo, Pons, Polishchuck, Brunetti-Pierri: "Geleophysic dysplasia: novel missense variants and insights into ADAMTSL2 intracellular trafficking." dans: Molecular genetics and metabolism reports, Vol. 21, pp. 100504, (2019) (PubMed).

Aviram, Zaffryar-Eilot, Hubmacher, Grunwald, Mäki, Myllyharju, Apte, Hasson: "Interactions between lysyl oxidases and ADAMTS proteins suggest a novel crosstalk between two extracellular matrix families." dans: Matrix biology : journal of the International Society for Matrix Biology, Vol. 75-76, pp. 114-125, (2019) (PubMed).

Détails sur ADAMTSL2

Antigène: ADAMTSL2 (ADAMTS-Like 2 (ADAMTSL2))

Autre désignation: ADAMTS like 2

Sujet: This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) and ADAMTS-like protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene lacks the protease domain, and is therefore of a member of the the ADAMTS-like protein subfamily. It is a secreted glycoprotein that binds the cell surface and extracellular matrix, it also interacts with latent transforming growth factor beta binding protein 1. Mutations in this gene have been associated with geleophysic dysplasia.

Cellular Localization: Secreted

Poids moléculaire: 105 kDa

ID gène: 9719

UniProt: Q86TH1