POM121 anticorps (N-Term)

N° du produit ABIN2855297

L’anticorps Lapin Polyclonal anti-POM121 a été validé pour WB, IF, IHC (p) et ICC. Il convient pour détecter POM121 dans des échantillons de Humain. Il y a 5+ publications disponibles.

Aperçu rapide pour POM121 anticorps (N-Term) (ABIN2855297)

Antigène: POM121 (POM121 Membrane Glycoprotein (POM121))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp POM121 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC)

Détail du produit anti-POM121 anticorps

Épitope: N-Term

Réactivité croisée: Humain, Souris

Attributs du produit: Rabbit Polyclonal antibody to POM121 (POM121 membrane glycoprotein (rat))
POM121 antibody [N2N3]

Purification: Purified by antigen-affinity chromatography.

Immunogène: Recombinant protein encompassing a sequence within the N-terminus region of human POM121. The exact sequence is proprietary.

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Commentaires:

Positive Control: A549

Validation: Orthogonal

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.16 mg/mL

Buffer: 1XPBS ( pH 7), 1 % BSA, 20 % Glycerol, 0.025 % ProClin 300

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Références pour anticorps anti-POM121 (ABIN2855297)

Ma, Li, Jia, Gong, Wang, Zhang, Gu, Tang: "POM121 is identified as a novel prognostic marker of oral squamous cell carcinoma." dans: Journal of Cancer, Vol. 10, Issue 19, pp. 4473-4480, (2019) (PubMed).

Rodriguez-Bravo, Pippa, Song, Carceles-Cordon, Dominguez-Andres, Fujiwara, Woo, Koh, Ertel, Lokareddy, Cuesta-Dominguez, Kim, Rodriguez-Fernandez, Li, Gordon, Hirschfield, Prats, Reddy, Fatatis et al.: "Nuclear Pores Promote Lethal Prostate Cancer by Increasing POM121-Driven E2F1, MYC, and AR Nuclear Import. ..." dans: Cell, Vol. 174, Issue 5, pp. 1200-1215.e20, (2019) (PubMed).

Jiang, Gan, Yen, Moussaud, McLean, Dickson: "Proaggregant nuclear factor(s) trigger rapid formation of α-synuclein aggregates in apoptotic neurons." dans: Acta neuropathologica, Vol. 132, Issue 1, pp. 77-91, (2017) (PubMed).

Schwartz, Travesa, Martell, Forbes: "Analysis of the initiation of nuclear pore assembly by ectopically targeting nucleoporins to chromatin." dans: Nucleus (Austin, Tex.), Vol. 6, Issue 1, pp. 40-54, (2015) (PubMed).

Chow, Elgort, Dasso, Powers, Ullman: "The SUMO proteases SENP1 and SENP2 play a critical role in nucleoporin homeostasis and nuclear pore complex function." dans: Molecular biology of the cell, Vol. 25, Issue 1, pp. 160-8, (2014) (PubMed).

Détails sur POM121

Antigène: POM121 (POM121 Membrane Glycoprotein (POM121))

Autre désignation: POM121 transmembrane nucleoporin

Sujet: The nuclear envelope creates distinct nuclear and cytoplasmic compartments in eukaryotic cells. It consists of two concentric membranes perforated by nuclear pores, large protein complexes that form aqueous channels to regulate the flow of macromolecules between the nucleus and the cytoplasm. These complexes are composed of at least 100 different polypeptide subunits, many of which belong to the nucleoporin family. This gene encodes a member of the FG-repeat-containing nucleoporins. The protein encoded by this gene is an integral membrane protein that localizes to the central spoke ring complex and participates in anchoring the nuclear pore complex to the nuclear envelope. Alternatively spliced variants that encode different protein isoforms have been described but the full-length nature of only one has been determined.

Cellular Localization: Nucleus , nuclear pore complex , Nucleus membrane, Single-pass membrane protein , Endoplasmic reticulum membrane, Single-pass membrane protein (By similarity)

Poids moléculaire: 128 kDa

ID gène: 9883

UniProt: Q96HA1