HSD17B4 anticorps

N° du produit ABIN2855717

L’anticorps Lapin Polyclonal anti-HSD17B4 a été validé pour WB, IHC (p), IF et ICC. Il convient pour détecter HSD17B4 dans des échantillons de Humain. Il y a 1 publication disponible.

Aperçu rapide pour HSD17B4 anticorps (ABIN2855717)

Antigène: HSD17B4 (Hydroxysteroid (17-Beta) Dehydrogenase 4 (HSD17B4))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp HSD17B4 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF), Immunocytochemistry (ICC)

Détail du produit anti-HSD17B4 anticorps

Réactivité croisée: Humain, Rat

Attributs du produit: Rabbit Polyclonal antibody to HSD17B4 (hydroxysteroid (17-beta) dehydrogenase 4)
HSD17B4 antibody

Purification: Purified by antigen-affinity chromatography.

Immunogène: Recombinant protein encompassing a sequence within the center region of human HSD17B4. The exact sequence is proprietary.

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Commentaires:

Positive Control: Rat heart

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: 0.1M Tris-Glycine ( pH 7), 10 % Glycerol, 0.01 % Thimerosal

Agent conservateur: Thimerosal (Merthiolate)

Précaution d'utilisation: This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Références pour anticorps anti-HSD17B4 (ABIN2855717)

Frasinyuk, Zhang, Wyrebek, Yu, Xu, Sviripa, Bondarenko, Xie, Ngo, Morris, Mohler, Fiandalo, Watt, Liu: "Developing antineoplastic agents that target peroxisomal enzymes: cytisine-linked isoflavonoids as inhibitors of hydroxysteroid 17-beta-dehydrogenase-4 (HSD17B4)." dans: Organic & biomolecular chemistry, Vol. 15, Issue 36, pp. 7623-7629, (2018) (PubMed).

Détails sur HSD17B4

Antigène: HSD17B4 (Hydroxysteroid (17-Beta) Dehydrogenase 4 (HSD17B4))

Autre désignation: hydroxysteroid 17-beta dehydrogenase 4

Sujet: The protein encoded by this gene is a bifunctional enzyme that is involved in the peroxisomal beta-oxidation pathway for fatty acids. It also acts as a catalyst for the formation of 3-ketoacyl-CoA intermediates from both straight-chain and 2-methyl-branched-chain fatty acids. Defects in this gene that affect the peroxisomal fatty acid beta-oxidation activity are a cause of D-bifunctional protein deficiency (DBPD). An apparent pseudogene of this gene is present on chromosome 8.

Cellular Localization: Peroxisome

Poids moléculaire: 80 kDa

ID gène: 3295

UniProt: P51659

Pathways: Monocarboxylic Acid Catabolic Process