PYGB anticorps (C-Term)

N° du produit ABIN2855804

L’anticorps Lapin Polyclonal anti-PYGB a été validé pour WB et IHC (p). Il convient pour détecter PYGB dans des échantillons de Humain et Souris. Il y a 2+ publications disponibles.

Aperçu rapide pour PYGB anticorps (C-Term) (ABIN2855804)

Antigène: PYGB (GPBB) (phosphorylase, Glycogen, Brain (GPBB))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PYGB est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-PYGB anticorps

Épitope: C-Term

Attributs du produit: Rabbit Polyclonal antibody to GPBB (phosphorylase, glycogen, brain)
GPBB antibody

Purification: Purified by antigen-affinity chromatography.

Immunogène: Recombinant protein encompassing a sequence within the C-terminus region of human GPBB. The exact sequence is proprietary.

Isotype: IgG

Information d'application

Indications d'application: Suggested dilution Reference IHC (Formalin-fixed paraffin-embedded sections) 1:100-1:1000* Western blot 1:500-1:3000* Not tested in other applications. *Optimal dilutions/concentrations should be determined by the researcher.Suggested dilutionReferenceIHC (Formalin-fixed paraffin-embedded sections)1:100-1:1000* Western blot1:500-1:3000*

Commentaires:

Positive Control: HepG2 , mouse brain

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.84 mg/mL

Buffer: 0.1M Tris, 0.1M Glycine, 10 % Glycerol ( pH 7). 0.01 % Thimerosal was added as a preservative.

Agent conservateur: Thimerosal (Merthiolate)

Précaution d'utilisation: This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Keep as concentrated solution. Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Références pour anticorps anti-PYGB (ABIN2855804)

Cooper, Pasini, Lambert, DAlessandro, Yao, Risner, Calkins: "Redistribution of metabolic resources through astrocyte networks mitigates neurodegenerative stress." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 117, Issue 31, pp. 18810-18821, (2020) (PubMed).

Geiszler, Ugun-Klusek, Lawler, Pardon, Yuchun, Bai, Daykin, Auer, Bedford: "Dynamic metabolic patterns tracking neurodegeneration and gliosis following 26S proteasome dysfunction in mouse forebrain neurons." dans: Scientific reports, Vol. 8, Issue 1, pp. 4833, (2019) (PubMed).

Détails sur PYGB

Antigène: PYGB (GPBB) (phosphorylase, Glycogen, Brain (GPBB))

Autre désignation: GPBB

Sujet: The protein encoded by this gene is a glycogen phosphorylase found predominantly in the brain. The encoded protein forms homodimers which can associate into homotetramers, the enzymatically active form of glycogen phosphorylase. The activity of this enzyme is positively regulated by AMP and negatively regulated by ATP, ADP, and glucose-6-phosphate. This enzyme catalyzes the rate-determining step in glycogen degradation.

Poids moléculaire: 97 kDa

ID gène: 5834

Pathways: Cellular Glucan Metabolic Process