RANGAP1 anticorps (N-Term)

N° du produit ABIN2856335

L’anticorps Lapin Polyclonal anti-RANGAP1 a été validé pour WB et IHC (p). Il convient pour détecter RANGAP1 dans des échantillons de Humain.

Aperçu rapide pour RANGAP1 anticorps (N-Term) (ABIN2856335)

Antigène: RANGAP1 (Ran GTPase Activating Protein 1 (RANGAP1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RANGAP1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-RANGAP1 anticorps

Épitope: N-Term

Réactivité croisée: Humain

Attributs du produit: Rabbit Polyclonal antibody to RanGAP1 (Ran GTPase activating protein 1)
RanGAP1 antibody [N1], N-term

Purification: Purified by antigen-affinity chromatography.

Immunogène: Carrier-protein conjugated synthetic peptide encompassing a sequence within the N-terminus region of human RanGAP1. The exact sequence is proprietary.

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:3000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Commentaires:

Positive Control: A431

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1XPBS ( pH 7), 10 % Glycerol, 0.01 % Thimerosal

Agent conservateur: Thimerosal (Merthiolate)

Précaution d'utilisation: This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Détails sur RANGAP1

Antigène: RANGAP1 (Ran GTPase Activating Protein 1 (RANGAP1))

Autre désignation: Ran GTPase activating protein 1

Sujet: RanGAP1, is a homodimeric 65-kD polypeptide that specifically induces the GTPase activity of RAN, but not of RAS by over 1,000-fold. RanGAP1 is the immediate antagonist of RCC1, a regulator molecule that keeps RAN in the active, GTP-bound state. The RANGAP1 gene encodes a 587-amino acid polypeptide. The sequence is unrelated to that of GTPase activators for other RAS-related proteins, but is 88 % identical to Fug1, the murine homolog of yeast Rna1p. RanGAP1 and RCC1 control RAN-dependent transport between the nucleus and cytoplasm. RanGAP1 is a key regulator of the RAN GTP/GDP cycle.

Cellular Localization: Cytoplasm , Nucleus membrane, Peripheral membrane protein, Cytoplasmic side , Kinetochore (By similarity)

Poids moléculaire: 64 kDa

ID gène: 5905

UniProt: P46060

Pathways: M Phase, Protein targeting to Nucleus