IPO7 anticorps (C-Term)

N° du produit ABIN2856366

Cet anticorps anti-IPO7 est un anticorps Lapin Polyclonal détectant IPO7 dans WB, IHC (p), IF et ICC. Adapté pour Humain.

Aperçu rapide pour IPO7 anticorps (C-Term) (ABIN2856366)

Antigène: IPO7 (Importin 7 (IPO7))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp IPO7 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF), Immunocytochemistry (ICC)

Classe de qualité: KO Validated

Détail du produit anti-IPO7 anticorps

Épitope: C-Term

Specificité: Knockdown/Knockout validation was supported by references (PMID:25999477)

Réactivité croisée: Humain

Attributs du produit: Rabbit Polyclonal antibody to Importin 7 (importin 7)
Importin 7 antibody [C3], C-term

Purification: Purified by antigen-affinity chromatography.

Immunogène: Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human Importin 7. The exact sequence is proprietary.

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Commentaires:

Positive Control: Jurkat

Validation: KO/KD

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1XPBS ( pH 7), 10 % Glycerol, 0.01 % Thimerosal

Agent conservateur: Thimerosal (Merthiolate)

Précaution d'utilisation: This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Détails sur IPO7

Antigène: IPO7 (Importin 7 (IPO7))

Autre désignation: importin 7

Sujet: The importin-alpha/beta complex and the GTPase Ran mediate nuclear import of proteins with a classical nuclear localization signal. The protein encoded by this gene is a member of a class of approximately 20 potential Ran targets that share a sequence motif related to the Ran-binding site of importin-beta. Similar to importin-beta, this protein prevents the activation of Ran's GTPase by RanGAP1 and inhibits nucleotide exchange on RanGTP, and also binds directly to nuclear pore complexes where it competes for binding sites with importin-beta and transportin. This protein has a Ran-dependent transport cycle and it can cross the nuclear envelope rapidly and in both directions. At least four importin beta-like transport receptors, namely importin beta itself, transportin, RanBP5 and RanBP7, directly bind and import ribosomal proteins.

Cellular Localization: Cytoplasm , Nucleus

Poids moléculaire: 120 kDa

ID gène: 10527

UniProt: O95373

Pathways: Protein targeting to Nucleus