ITPK1 anticorps

N° du produit ABIN2856549

Cet anticorps anti-ITPK1 est un anticorps Lapin Polyclonal détectant ITPK1 dans WB, IF et ICC. Adapté pour Humain. Ce Primary Antibody a été cité dans 1 publication.

Aperçu rapide pour ITPK1 anticorps (ABIN2856549)

Antigène: ITPK1 (Inositol-Tetrakisphosphate 1-Kinase (ITPK1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ITPK1 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Immunocytochemistry (ICC)

Détail du produit anti-ITPK1 anticorps

Réactivité croisée: Humain

Attributs du produit: Rabbit Polyclonal antibody to ITPK1 (inositol 1,3,4-triphosphate 5/6 kinase)
ITPK1 antibody [N3C3]

Purification: Purified by antigen-affinity chromatography.

Immunogène: Recombinant protein encompassing a sequence within the center region of human ITPK1. The exact sequence is proprietary.

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Commentaires:

Positive Control: A431

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.53 mg/mL

Buffer: 0.1M Tris-Glycine ( pH 7), 10 % Glycerol, 0.01 % Thimerosal

Agent conservateur: Thimerosal (Merthiolate)

Précaution d'utilisation: This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Références pour anticorps anti-ITPK1 (ABIN2856549)

Dovey, Diep, Clarke, Hale, McNamara, Guo, Brown, Cao, Grace, Gough, Bertin, Dixon, Fiedler, Mocarski, Kaiser, Moldoveanu, York, Carette: "MLKL Requires the Inositol Phosphate Code to Execute Necroptosis." dans: Molecular cell, Vol. 70, Issue 5, pp. 936-948.e7, (2019) (PubMed).

Détails sur ITPK1

Antigène: ITPK1 (Inositol-Tetrakisphosphate 1-Kinase (ITPK1))

Autre désignation: inositol-tetrakisphosphate 1-kinase

Sujet: Kinase that can phosphorylate various inositol polyphosphate such as Ins(3,4,5,6)P4 or Ins(1,3,4)P3. Phosphorylates Ins(3,4,5,6)P4 at position 1 to form Ins(1,3,4,5,6)P5. This reaction is thought to have regulatory importance, since Ins(3,4,5,6)P4 is an inhibitor of plasma membrane Ca(2+)-activated Cl(-) channels, while Ins(1,3,4,5,6)P5 is not. Also phosphorylates Ins(1,3,4)P3 on O-5 and O-6 to form Ins(1,3,4,6)P4, an essential molecule in the hexakisphosphate (InsP6) pathway. Also acts as an inositol polyphosphate phosphatase that dephosphorylate Ins(1,3,4,5)P4 and Ins(1,3,4,6)P4 to Ins(1,3,4)P3, and Ins(1,3,4,5,6)P5 to Ins(3,4,5,6)P4. May also act as an isomerase that interconverts the inositol tetraphosphate isomers Ins(1,3,4,5)P4 and Ins(1,3,4,6)P4 in the presence of ADP and magnesium. Probably acts as the rate-limiting enzyme of the InsP6 pathway. Modifies TNF-alpha-induced apoptosis by interfering with the activation of TNFRSF1A-associated death domain.

Poids moléculaire: 46 kDa

ID gène: 3705

UniProt: Q13572