SMC1A anticorps (N-Term)

N° du produit ABIN2856699

Détail du produit anti-SMC1A anticorps

Antigène: SMC1A (Structural Maintenance of Chromosomes 1A (SMC1A))

Épitope: N-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SMC1A est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP)

Réactivité croisée: Humain, Poisson zèbre (Danio rerio)

Attributs du produit: Rabbit Polyclonal antibody to SMC1A (structural maintenance of chromosomes 1A)
SMC1A antibody [N1N2], N-term

Purification: Purified by antigen-affinity chromatography.

Immunogène: Recombinant protein encompassing a sequence within the N-terminus region of human SMC1A. The exact sequence is proprietary.

Isotype: IgG

Information d'application

Indications d'application: WB: 1:1000-1:10000. IHC-P: 1:100-1:1000. IP: 1:100-1:500. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Commentaires:

Positive Control: Molt-4

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: 0.1M Tris-Glycine ( pH 7), 10 % Glycerol, 0.01 % Thimerosal

Agent conservateur: Thimerosal (Merthiolate)

Précaution d'utilisation: This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Détails sur SMC1A

Antigène: SMC1A (Structural Maintenance of Chromosomes 1A (SMC1A))

Autre désignation: structural maintenance of chromosomes 1A (SMC1A Produits)

Synonymes: anticorps CDLS2, anticorps DXS423E, anticorps SB1.8, anticorps SMC1, anticorps SMC1L1, anticorps SMC1alpha, anticorps SMCB, anticorps SMC-1A, anticorps NV15570, anticorps 5830426I24Rik, anticorps Sb1.8, anticorps Smc1, anticorps Smc1alpha, anticorps Smc1l1, anticorps Smcb, anticorps mKIAA0178, anticorps smc1, anticorps smc1a, anticorps smc1l1, anticorps xSMC1, anticorps smc1aa, anticorps structural maintenance of chromosomes 1A, anticorps structural maintenance of chromosomes 1A b, anticorps structural maintenance of chromosomes 1A L homeolog, anticorps SMC1A, anticorps smc1a, anticorps Smc1a, anticorps smc1ab, anticorps smc1a.L

Sujet: Proper cohesion of sister chromatids is a prerequisite for the correct segregation of chromosomes during cell division. The cohesin multiprotein complex is required for sister chromatid cohesion. This complex is composed partly of two structural maintenance of chromosomes (SMC) proteins, SMC3 and either SMC1L2 or the protein encoded by this gene. Most of the cohesin complexes dissociate from the chromosomes before mitosis, although those complexes at the kinetochore remain. Therefore, the encoded protein is thought to be an important part of functional kinetochores. In addition, this protein interacts with BRCA1 and is phosphorylated by ATM, indicating a potential role for this protein in DNA repair. This gene, which belongs to the SMC gene family, is located in an area of the X-chromosome that escapes X inactivation.

Cellular Localization: Nucleus , Kinetochore

Poids moléculaire: 143 kDa

ID gène: 8243

UniProt: Q14683

Pathways: Stem Cell Maintenance