SSRP1 anticorps

N° du produit ABIN2856824

L’anticorps Lapin Polyclonal anti-SSRP1 a été validé pour WB, IP et IHC (p). Il convient pour détecter SSRP1 dans des échantillons de Humain.

Aperçu rapide pour SSRP1 anticorps (ABIN2856824)

Antigène: SSRP1 (Structure Specific Recognition Protein 1 (SSRP1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SSRP1 est non-conjugé

Application: Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Classe de qualité: KO Validated

Détail du produit anti-SSRP1 anticorps

Specificité: Knockdown/Knockout validation was supported by references (PMID:26990993)

Réactivité croisée: Humain

Attributs du produit: Rabbit polyclonal antibody to SSRP1 (structure specific recognition protein 1)
SSRP1 antibody [N1N3]

Purification: Purified by antigen-affinity chromatography.

Immunogène: Recombinant protein encompassing a sequence within the center region of human SSRP1. The exact sequence is proprietary.

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:3000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Commentaires:

Positive Control: Molt-4 , 293T , A431 , HeLa , HepG2 , Jurkat

Validation: KO/KD

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: 0.1M Tris-Glycine ( pH 7), 10 % Glycerol, 0.01 % Thimerosal

Agent conservateur: Thimerosal (Merthiolate)

Précaution d'utilisation: This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Détails sur SSRP1

Antigène: SSRP1 (Structure Specific Recognition Protein 1 (SSRP1))

Autre désignation: structure specific recognition protein 1

Sujet: The protein encoded by this gene is a subunit of a heterodimer that, along with SUPT16H, forms chromatin transcriptional elongation factor FACT. FACT interacts specifically with histones H2A/H2B to effect nucleosome disassembly and transcription elongation. FACT and cisplatin-damaged DNA may be crucial to the anticancer mechanism of cisplatin. This encoded protein contains a high mobility group box which most likely constitutes the structure recognition element for cisplatin-modified DNA. This protein also functions as a co-activator of the transcriptional activator p63. An alternatively spliced transcript variant of this gene has been described, but its full-length nature is not known.

Cellular Localization: Nucleus

Poids moléculaire: 81 kDa

ID gène: 6749

UniProt: Q08945

Pathways: Chromatin Binding