FKBP4 anticorps (full length, N-Term)

N° du produit ABIN2962775

Cet anticorps anti-FKBP4 Monoclonal Souris (Clone Hi52C) (ABIN2962775) détecte spécifiquement FKBP4 dans WB, IHC, IP, ICC et FACS. L’anticorps est réactif avec des échantillons de Humain, Souris, Rat, Hamster et Chien.

Aperçu rapide pour FKBP4 anticorps (full length, N-Term) (ABIN2962775)

Antigène: FKBP4 (FK506 Binding Protein 4, 59kDa (FKBP4))

Reactivité: Humain, Souris, Rat, Hamster, Chien

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp FKBP4 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunocytochemistry (ICC), Flow Cytometry (FACS)

Clone: Hi52C

Détail du produit anti-FKBP4 anticorps

Épitope: full length, N-Term

Specificité: Reacts with human FKBP52. Cross-reacts with mouse, rat, canine and hamster protein.

Purification: Purified (protein G)

Immunogène: Recombinant full-length FKBP52 with an N-terminal polyhistidine tag.

Isotype: IgG1

Information d'application

Indications d'application: Working dilution: Optimal dilution should be determined by the end user.
The following are guidelines only :
FC(1-2 μg for 10.6 cells) IHC(4 - 5 μg/mL) WB(0.5 - 1 μg/mL)

Positive control: HeLa cell lysate, rat kidney and rat/mouse testes tissue.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS, pH 7.4, glycerol 50 % .

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Dilute in PBS or medium that is identical to that used in the assay system.

Stock: -20 °C

Stockage commentaire: Stable for at least one year at -20°C. Avoid multiple freeze-thaw cycles.

Date de péremption: 12 months

Détails sur FKBP4

Antigène: FKBP4 (FK506 Binding Protein 4, 59kDa (FKBP4))

Autre désignation: FKBP52

Sujet: FK506-binding proteins, FKBP51 and FKBP52, are high molecular weight immunophilins that are part of the mature glucocorticoid receptor heterocomplex. The N-terminal domains of these proteins bind FK506 and have peptidyl-prolyl isomerase activity that converts prolyl peptide bonds within target proteins from cis- to transproline. The C-terminal domains contain the tetratricopeptide repeats that are involved in protein-protein interactions with Hsp90. Although FKBP52 and FKBP51 share ~75 % sequence similarity, they affect hormone binding by glucocorticoid receptors differently and have different Hsp90-binding characteristics. In addition, FKBP51 is linked to the progesterone receptor while FKBP52 is linked to progesterone, androgen, and glucocorticoid receptors.

Peptidyl-prolyl cis-trans isomerase FKBP4, PPIase FKBP4 51 kDa FK506-binding protein, FKBP51 52 kDa FK506-binding protein, FKBP-52 59 kDa immunophilin, p59 FK506-binding protein 4, FKBP-4 FKBP59 HSP-binding immunophilin, HBI Immunophilin FKBP52 Rotamase Gene name : FKBP4

ID gène: 2288

UniProt: Q02790

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway