IL-25 anticorps (AA 115-132)

N° du produit ABIN302245

Cet anticorps Souris Monoclonal détecte spécifiquement IL-25 dans WB et IHC (p). Il présente une réactivité avec des échantillons de Humain et Souris.

Aperçu rapide pour IL-25 anticorps (AA 115-132) (ABIN302245)

Antigène: IL-25 (IL25) (Interleukin 25 (IL25))

Reactivité: Humain, Souris

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp IL-25 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: 68C1039-2

Détail du produit anti-IL-25 anticorps

Épitope: AA 115-132

Specificité: This antibody detects Interleukin 17E (IL17E) (IL25).

Réactivité croisée (Details): Species reactivity (expected):Mouse.
Species reactivity (tested):Human.

Attributs du produit: Synonyms: IL-25, IL17E, IL-17E, Interleukin-17E

Purification: Protein G Chromatography.

Immunogène: A synthetic peptide of amino acids 115-132, obtained from the human IL-17E proteinsequence.

Isotype: IgG1

Information d'application

Indications d'application: Western blot (2 μg/mL). Immunohistochemistry on Paraffin Sections (10 μg/mL). Antigen retrieval: Steam slides in 0.01 M sodium citrate buffer, pH 6.0, at 99-100 °C for 20 min. Remove fromheat and let stand at room temperature in buffer for 20 min. Rinse in 1x TBS with Tween(TBST) for 1 min. at room temperature.

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: PBS containing 0.05 % Sodium Azide as preservative.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or(in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.

Date de péremption: 12 months

Détails sur IL-25

Antigène: IL-25 (IL25) (Interleukin 25 (IL25))

Autre désignation: Interleukin-25 / IL25

Sujet: Recently, a number of cytokines belonging to the interleukin (IL)-17 family have been identified. These are termed as IL-17B, IL-17C and IL-17E. IL-17 is a potent proinflammatory cytokine that plays roles in a number of diseases including rheumatoid arthritis, multiple sclerosis, and promotion of tumor growth. IL-17B, C, and E like IL-17 are able to induce proinflammatory responses. However, they do not bind to the IL-17 receptor suggesting that additional IL-17R related receptor might exist. Receptor for IL-17B and IL-17E has been independently isolated by Shi, et al and Lee, et al. and has been designated as EV127 (in mouse) and IL-17Rh1 (in human), respectively. IL-17E induces activation of NF-kB pathway and like IL-17 also induces production of IL-8. The IL17 proteins are a family of potent cytokines that act to induce proinflammatory responses. Studies have shown that IL17E binds strongly to IL17RB. Receptor binding of ligand has been shown to lead to the activation of nuclear factor kappa-B and production of IL8. Exposure of mice to IL17 resulted in a Th-2 like response characterized by increased serum IgE, IgG1 and IgA levels, blood eosinophilia, increased lymphocytes and neutrophils, and pathological changes in the tissues that included eosinophilic infiltrates, increased mucus production, B-lymphocyte hyperplasia and epithelial cell hyperplasia/hypertrophy.Synonyms: IL-17E, IL-25, IL17E, Interleukin-17E

ID gène: 64806

UniProt: Q9H293