DNMT3A anticorps (AA 500-700)

N° du produit ABIN3022834

Cet anticorps Lapin Polyclonal détecte spécifiquement DNMT3A dans WB et IP. Il présente une réactivité envers Humain et a été mentionné dans 3+ publications.

Aperçu rapide pour DNMT3A anticorps (AA 500-700) (ABIN3022834)

Antigène: DNMT3A (DNA (Cytosine-5-)-Methyltransferase 3 alpha (DNMT3A))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp DNMT3A est non-conjugé

Application: Western Blotting (WB), Immunoprecipitation (IP)

Détail du produit anti-DNMT3A anticorps

Épitope: AA 500-700

Séquence: SVTQKHIQEW GPFDLVIGGS PCNDLSIVNP ARKGLYEGTG RLFFEFYRLL HDARPKEGDD RPFFWLFENV VAMGVSDKRD ISRFLESNPV MIDAKEVSAA HRARYFWGNL PGMNRPLAST VNDKLELQEC LEHGRIAKFS KVRTITTRSN SIKQGKDQHF PVFMNEKEDI LWCTEMERVF GFPVHYTDVS NMSRLARQRL L

Réactivité croisée: Humain, Souris, Rat

Attributs du produit: Polyclonal Antibodies

Purification: Affinity purification

Immunogène: Recombinant fusion protein containing a sequence corresponding to amino acids 500-700 of human DNMT3A (NP_715640.2).

Isotype: IgG

Information d'application

Indications d'application: WB,1:500 - 1:2000,IP,1:50 - 1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid freeze / thaw cycles

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Références pour anticorps anti-DNMT3A (ABIN3022834)

Zhao, Lei, Zhang, Zheng, Wang, Zhao, Li, Ye, Li, Wei, Wu: "Global histone modification profiling reveals the epigenomic dynamics during malignant transformation in a four-stage breast cancer model." dans: Clinical epigenetics, Vol. 8, pp. 34, (2016) (PubMed).

Xi, Gao, Yang, Ye, Zhang, Wu, Jiang, Zhang: "Anticancer drugs induce hypomethylation of the acetylcholinesterase promoter via a phosphorylated-p38-DNMT1-AChE pathway in apoptotic hepatocellular carcinoma cells." dans: The international journal of biochemistry & cell biology, Vol. 68, pp. 21-32, (2016) (PubMed).

Zeng, Huang, Wang, Wu, Wu, Huang: "Galangin-induced down-regulation of BACE1 by epigenetic mechanisms in SH-SY5Y cells." dans: Neuroscience, Vol. 294, pp. 172-81, (2015) (PubMed).

Détails sur DNMT3A

Antigène: DNMT3A (DNA (Cytosine-5-)-Methyltransferase 3 alpha (DNMT3A))

Autre désignation: DNMT3A

Sujet: CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase that is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes to the cytoplasm and nucleus and its expression is developmentally regulated.,DNMT3A,DNMT3A2,M.HsaIIIA,TBRS,DNMT3A,Epigenetics & Nuclear Signaling,Chromatin Modifying Enzymes,DNA methylation,DNMT3A

Poids moléculaire: 16 kDa/81 kDa/101 kDa

ID gène: 1788

UniProt: Q9Y6K1