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LAMP3 anticorps

LAMP3 Reactivité: Humain IF, IHC (p), FACS Hôte: Souris Monoclonal LAMP3-968 unconjugated
N° du produit ABIN3023870
  • Antigène Voir toutes LAMP3 Anticorps
    LAMP3 (Lysosomal-Associated Membrane Protein 3 (LAMP3))
    Reactivité
    • 56
    • 4
    • 4
    Humain
    Hôte
    • 48
    • 6
    • 1
    • 1
    Souris
    Clonalité
    • 52
    • 4
    Monoclonal
    Conjugué
    • 28
    • 5
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp LAMP3 est non-conjugé
    Application
    • 45
    • 28
    • 13
    • 13
    • 10
    • 6
    • 4
    • 4
    • 3
    • 3
    • 1
    • 1
    • 1
    Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS)
    Attributs du produit
    This mAb recognizes protein of 26 kDa-60 kDa, which is identified as CD63/LAMP3. Its epitope is different from that of mAb LAMP3/529. The tetraspanins are integral membrane proteins expressed on cell surface and granular membranes of hematopoietic cells and are components of multi-molecular complexes with specific integrins. The tetraspanin CD63/LAMP3 is a lysosomal membrane glycoprotein that translocates to the plasma membrane after platelet activation. It is expressed on activated platelets, monocytes and macrophages, and is weakly expressed on granulocytes, T cell and B cells. It is located on the basophilic granule membranes and on the plasma membranes of lymphocytes and granulocytes. CD63 is a member of the TM4 superfamily of leukocyte glycoproteins that includes CD9, CD37 and CD53, which contain four transmembrane regions. CD63/LAMP3 may play a role in phagocytic and intracellular lysosome-phagosome fusion events. Deficiency is associated with Hermansky-Pudlak syndrome and is strongly expressed during the early stages of melanoma progression.
    Purification
    Protein G affinity chromatography
    Immunogène
    Recombinant human full-length protein was used as the immunogen for the LAMP3 antibody.
    Clone
    LAMP3-968
    Isotype
    IgG2a kappa
    Top Product
    Discover our top product LAMP3 Anticorps primaire
  • Indications d'application
    Optimal dilution of the LAMP3 antibody should be determined by the researcher.

    1. Staining of formalin-fixed tissues requires boiling tissue sections in 10  mM Citrate buffer,  pH 6.0, for 10-20 min followed by cooling at RT for 20 min.
    2. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.\. Flow Cytometry: 0.5-1 μg/million cells in 0.1ml,Immunofluorescence: 0.5-1 μg/mL,Immunohistochemistry (FFPE): 1-2 μg/mL for 30 min at RT (1),Prediluted format: incubate for 30 min at RT (2)

    Restrictions
    For Research Use only
  • Concentration
    0.2 mg/mL
    Buffer
    0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Stockage commentaire
    Store the LAMP3 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).
  • Antigène
    LAMP3 (Lysosomal-Associated Membrane Protein 3 (LAMP3))
    Autre désignation
    LAMP3 (LAMP3 Produits)
    Synonymes
    anticorps DC-LAMP, anticorps CD208, anticorps DC LAMP, anticorps DCLAMP, anticorps LAMP, anticorps LAMP-3, anticorps TSC403, anticorps 1200002D17Rik, anticorps Cd208, anticorps lysosomal associated membrane protein 3, anticorps lysosomal-associated membrane protein 3, anticorps LAMP3, anticorps Lamp3
    Sujet
    This mAb recognizes protein of 26  kDa-60  kDa, which is identified as CD63/LAMP3. Its epitope is different from that of mAb LAMP3/529. The tetraspanins are integral membrane proteins expressed on cell surface and granular membranes of hematopoietic cells and are components of multi-molecular complexes with specific integrins. The tetraspanin CD63/LAMP3 is a lysosomal membrane glycoprotein that translocates to the plasma membrane after platelet activation. It is expressed on activated platelets, monocytes and macrophages, and is weakly expressed on granulocytes, T cell and B cells. It is located on the basophilic granule membranes and on the plasma membranes of lymphocytes and granulocytes. CD63 is a member of the TM4 superfamily of leukocyte glycoproteins that includes CD9, CD37 and CD53, which contain four transmembrane regions. CD63/LAMP3 may play a role in phagocytic and intracellular lysosome-phagosome fusion events. Deficiency is associated with Hermansky-Pudlak syndrome and is strongly expressed during the early stages of melanoma progression.
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