FLI1 anticorps (AA 107-216)

N° du produit ABIN3024863

Cet anticorps Souris Monoclonal détecte spécifiquement FLI1 dans WB. Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour FLI1 anticorps (AA 107-216) (ABIN3024863)

Antigène: FLI1 (Friend Leukemia Virus Integration 1 (FLI1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp FLI1 est non-conjugé

Application: Western Blotting (WB)

Classe de qualité: Carrier-free

Clone: FLVI1-1

Détail du produit anti-FLI1 anticorps

Épitope: AA 107-216

Fonction: FLI1 Antibody (azide and preservative free)

Purification: Protein G affinity chromatography

Immunogène: Human partial recombinant protein (amino acids 107-216) was used as the immunogen for this FLI1 antibody.

Isotype: IgG1, kappa

Information d'application

Indications d'application: The concentration stated for each application is a general starting point. Variations in protocols, secondaries and substrates may require the FLI1 antibody to be titered up or down for optimal performance.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Agent conservateur: Azide free

Stock: 4 °C,-20 °C

Stockage commentaire: Store the FLI1 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Détails sur FLI1

Antigène: FLI1 (Friend Leukemia Virus Integration 1 (FLI1))

Autre désignation: FLI1

Sujet: Friend leukemia integration 1 is a member of the ETS family of DNA binding transcription factors that is involved in cellular proliferation and tumorigenesis. Members of the Ets gene family share a highly conserved carboxy-terminal domain containing a sequence related to the SV40 large T antigen nuclear localization signal sequence. Approximately 90 % of Ewing's Sarcoma (EWS) / Primitive Neuroectodermal Tumors (PNET) have a specific translocation, t(11,22)(q24,q12), which results in fusion of EWS to Fli-1, and production of an EWS-Fli-1 fusion protein. Among normal tissues only endothelial cells and small lymphocytes express Fli-1. This protein is expressed in majority of vascular tumors including angiosarcomas, hemangioendotheliomas, hemangiomas, and Kaposi's Sarcomas. High sensitivity and specificity of Fli-1 equals to or exceeds that of the established vascular markers like CD31, CD34, and Factor VIII.