TOX3 anticorps (AA 200-400)

N° du produit ABIN3025030

Cet anticorps anti-TOX3 Monoclonal Souris (Clone TOX3-1123) (ABIN3025030) détecte spécifiquement TOX3 dans WB. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour TOX3 anticorps (AA 200-400) (ABIN3025030)

Antigène: TOX3 (TOX High Mobility Group Box Family Member 3 (TOX3))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp TOX3 est non-conjugé

Application: Western Blotting (WB)

Classe de qualité: Carrier-free

Clone: TOX3-1123

Détail du produit anti-TOX3 anticorps

Épitope: AA 200-400

Fonction: TOX3 Antibody (azide and preservative free)

Purification: Protein G affinity chromatography

Immunogène: A recombinant fragment (139 amino acid residues around aa 200-400) from the human protein was used as the immunogen for the TOX3 antibody.

Isotype: IgG2b, kappa

Information d'application

Indications d'application: Optimal dilution of the TOX3 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Agent conservateur: Azide free

Stock: 4 °C,-20 °C

Stockage commentaire: Store the TOX3 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Détails sur TOX3

Antigène: TOX3 (TOX High Mobility Group Box Family Member 3 (TOX3))

Autre désignation: TOX3

Sujet: It recognizes a 63 kDa protein, which is identified as TOX3. It contains a high mobility group (HMG)-box, which regulates Ca2+-dependent transcription in neurons through interaction with the cAMP-response-element-binding protein (CREB). TOX3 appears to be associated with breast cancer susceptibility and is expressed downstream of a cytoprotective cascade together with CITED1, a transcriptional regulator that does not bind directly to DNA. TOX3 is predominantly expressed in the brain and forms homodimers. TOX3 overexpression protects neuronal cells from cell death caused by endoplasmic reticulum stress or BAX overexpression through the induction of anti-apoptotic transcripts and repression of pro-apoptotic transcripts.

UniProt: O15405

Pathways: Chromatin Binding