PAX6 anticorps

N° du produit ABIN3025378

Cet anticorps anti-PAX6 Monoclonal Souris (Clone PAX6-498) (ABIN3025378) détecte spécifiquement PAX6 dans WB. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour PAX6 anticorps (ABIN3025378)

Antigène: PAX6 (Paired Box 6 (PAX6))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp PAX6 est non-conjugé

Application: Western Blotting (WB)

Classe de qualité: Carrier-free

Clone: PAX6-498

Détail du produit anti-PAX6 anticorps

Fonction: PAX6 Antibody (azide and preservative free)

Purification: Protein G purified antibody

Immunogène: Recombinant human PAX6 protein was used as the immunogen for this antibody.

Isotype: IgG1, kappa

Information d'application

Indications d'application: The concentration stated for each application is a general starting point. Variations in protocols, secondaries and substrates may require the antibody to be titered up or down for optimal performance.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Agent conservateur: Azide free

Stock: 4 °C,-20 °C

Stockage commentaire: Store the PAX6 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Détails sur PAX6

Antigène: PAX6 (Paired Box 6 (PAX6))

Autre désignation: PAX6

Sujet: PAX genes contain paired domains with strong homology to genes in Drosophila, which are involved in programming early development. Lesions in the PAX6 gene account for most cases of aniridia, a congenital malformation of the eye, chiefly characterized by iris hypoplasia, which can cause blindness. PAX6 is involved in other anterior segment malformations besides aniridia, such as Peters' anomaly, a major error in the embryonic development of the eye with corneal clouding with variable iridolenticulocorneal adhesions. The PAX6 gene encodes a transcriptional regulator that recognizes target genes through its paired-type DNA-binding domain. The paired domain is composed of two distinct DNA-binding subdomains, the amino-terminal subdomain and the carboxy-terminal subdomain, which bind respective consensus DNA sequences. The human PAX6 gene produces two alternatively spliced isoforms that have the distinct structure of the paired domain.

Pathways: Peptide Hormone Metabolism, Carbohydrate Homeostasis