TTF1 anticorps

N° du produit ABIN3025855

Cet anticorps anti-TTF1 Monoclonal Souris (Clone 8G7G3-1-NX2-1-690) (ABIN3025855) détecte spécifiquement TTF1 dans IF, IHC (p) et FACS. L’anticorps est réactif avec des échantillons de Humain, Rat et Souris.

Aperçu rapide pour TTF1 anticorps (ABIN3025855)

Antigène: TTF1 (Transcription Termination Factor, RNA Polymerase I (TTF1))

Reactivité: Humain, Rat, Souris

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp TTF1 est non-conjugé

Application: Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS)

Classe de qualité: Carrier-free

Clone: 8G7G3-1-NX2-1-690

Détail du produit anti-TTF1 anticorps

Fonction: TTF-1 Antibody Cocktail (azide and preservative free)

Purification: Protein G affinity chromatography

Immunogène: Recombinant protein was used as the immunogen for the TTF-1 antibody cocktail.

Isotype: IgG1, kappa

Information d'application

Indications d'application: Optimal dilution of the TTF-1 antibody cocktail should be determined by the researcher.

1. Staining of formalin/paraffin tissues requires boiling tissue sections in 10 mM Citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 min.
2. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Agent conservateur: Azide free

Stock: 4 °C,-20 °C

Stockage commentaire: Store the TTF-1 antibody cocktail at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Détails sur TTF1

Antigène: TTF1 (Transcription Termination Factor, RNA Polymerase I (TTF1))

Autre désignation: TTF-1

Sujet: Recognizes a protein of 40 kDa, identified as Thyroid transcription factor-1, also called NKX2.1. TTF-1 is a member of the NKx2 family of homeodomain transcription factors. It is expressed in epithelial cells of the thyroid gland and the lung. Nuclei from liver, stomach, pancreas, small intestine, colon, kidney, breast, skin, testes, pituitary, prostate, and adrenal glands are unreactive. Anti-TTF-1 is useful in differentiating primary adenocarcinoma of the lung from metastatic carcinomas originating in the breast, mediastinal germ cell tumors, and malignant mesothelioma. It can also be used to differentiate small cell lung carcinoma from lymphoid infiltrates. Loss of TTF-1 expression in non-small cell lung carcinoma has been associated with aggressive behavior of such neoplasms. TTF-1 reactivity is also seen in thyroid malignancies.

UniProt: P43699

Pathways: Thyroid Hormone Synthesis, Regulation of Systemic Arterial Blood Pressure by Hormones, Feeding Behaviour