CACYBP anticorps (Middle Region)

N° du produit ABIN3029276

L’anticorps anti-CACYBP Polyclonal Lapin est utilisé pour la détection de CACYBP dans des échantillons de Humain, Souris et Rat. Il a été validé pour WB, IF et FACS.

Aperçu rapide pour CACYBP anticorps (Middle Region) (ABIN3029276)

Antigène: CACYBP (Calcyclin Binding Protein (CACYBP))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CACYBP est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS)

Détail du produit anti-CACYBP anticorps

Épitope: Middle Region

Fonction: SIP Antibody / SIAH Interacting Protein / CACYBP

Séquence: NTRWDYLTQV EKECKE

Purification: Antigen affinity

Immunogène: An amino acid sequence from the middle region of human SIAH Interacting Protein (NTRWDYLTQVEKECKE) was used as the immunogen for this SIP antibody (100% homologous in human, mouse and rat).

Isotype: IgG

Information d'application

Indications d'application: The stated application concentrations are suggested starting amounts. Titration of the SIP antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the SIP antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur CACYBP

Antigène: CACYBP (Calcyclin Binding Protein (CACYBP))

Autre désignation: SIP

Sujet: CACYBP (Calcyclin-binding protein), also called SIP (SIAH Interacting Protein), is a protein that in humans is encoded by the CACYBP gene. The full-length SIP cDNA encodes a predicted 228-amino acid protein. Sequence analysis of the shortest cDNA derived by 2-hybrid screening revealed an 8-amino acid difference in the deduced open reading frame followed by a stop codon, resulting in a predicted 80-amino acid protein, SIP-short (SIPS). The CACYBP gene is mapped on 1q25.1. It may be involved in calcium-dependent ubiquitination and subsequent proteosomal degradation of target proteins. It probably serves as a molecular bridge in ubiquitin E3 complexes and participates in the ubiquitin-mediated degradation of beta-catenin. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. The C-terminal region of SIP that is homologous to SGT1 was able to complement defects in yeast strains containing SGT1 mutant alleles, demonstrating conservation of SGT1 and SIP protein function.

UniProt: Q9HB71

Pathways: Response to Growth Hormone Stimulus