ANG2 anticorps (AA 19-348)

N° du produit ABIN3029946

Détail du produit anti-ANG2 anticorps

Antigène: ANG2 (Angiogenin, Ribonuclease A Family, Member 2 (ANG2))

Épitope: AA 19-348

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ANG2 est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: Antigen affinity

Immunogène: Human partial recombinant protein (AA 19-348) was used as the immunogen for this ANG2 antibody.

Isotype: IgG

Information d'application

Indications d'application: The stated application concentrations are suggested starting amounts. Titration of the ANG2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. IHC (Paraffin): 0.5-1 μg/mL

Restrictions: For Research Use only

Stockage

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: -20 °C

Stockage commentaire: After reconstitution, the ANG2 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Détails sur ANG2

Antigène: ANG2 (Angiogenin, Ribonuclease A Family, Member 2 (ANG2))

Autre désignation: ANG2 (ANG2 Produits)

Synonymes: anticorps Angrp, anticorps Rnase5b, anticorps angiogenin, ribonuclease A family, member 2, anticorps angiogenin 2, anticorps Ang2, anticorps ANG2

Sujet: Angiopoietin 2, also known as ANG2, is a protein that in humans is encoded by the ANGPT2 gene. It is mapped to 8p23.1. ANGPT2 is a naturally occurring antagonist of ANGPT1 that competes for binding to the TIE2 receptor and blocks ANGPT1-induced TIE2 autophosphorylation during vasculogenesis. The encoded protein disrupts the vascular remodeling ability of ANGPT1 and may induce endothelial cell apoptosis. ANGPT2 was significantly increased in plasma and alveolar edema fluid in adults with acute lung injury compared to controls or patients with hydrostatic pulmonary edema, tracheal. ANGPT2 was also significantly increased in neonates with respiratory distress syndrome who developed bronchopulmonary edema. It is also a mediator of epithelial necrosis with an important role in hyperoxic acute lung injury and pulmonary edema.

ID gène: 285

Pathways: Carbohydrate Homeostasis