Aryl Hydrocarbon Receptor anticorps (AA 832-848)

N° du produit ABIN3030027

Cet anticorps anti-Aryl Hydrocarbon Receptor Polyclonal Lapin (ABIN3030027) détecte spécifiquement Aryl Hydrocarbon Receptor dans WB, IF, IHC (p) et FACS. L’anticorps est réactif avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour Aryl Hydrocarbon Receptor anticorps (AA 832-848) (ABIN3030027)

Antigène: Aryl Hydrocarbon Receptor (AHR)

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Aryl Hydrocarbon Receptor est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS)

Détail du produit anti-Aryl Hydrocarbon Receptor anticorps

Épitope: AA 832-848

Fonction: Aryl hydrocarbon Receptor Antibody / AHR

Purification: Antigen affinity

Immunogène: Amino acids 832-848 (HPSEARPFPDLTSSGFL-human) were used as the immunogen for this Aryl hydrocarbon Receptor antibody.

Isotype: IgG

Information d'application

Indications d'application: The stated application concentrations are suggested starting amounts. Titration of the Aryl hydrocarbon Receptor antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the Aryl hydrocarbon Receptor antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur Aryl Hydrocarbon Receptor

Antigène: Aryl Hydrocarbon Receptor (AHR)

Autre désignation: Aryl hydrocarbon Receptor

Sujet: Aryl hydrocarbon receptor, also called AHR and bHLHe76, is a member of the family of basic helix-loop-helix transcription factors. It is a cytosolic transcription factor that is normally inactive, bound to several co-chaperones. The gene is mapped on 7p21.1. Estrogenic actions of AHR agonists were detected in wildtype ovariectomized mouse uteri, but were absent in Ahr-/- or Er-alpha -/- ovariectomized mice. CD4-positive cells from mice lacking the recepter developed Th17 responses but failed to produce IL-22 and did not show enhanced Th17 development. Activation of Aryl hydrocarbon receptor during induction of EAE accelerated disease onset and increased pathology in wildtype mice, but not in -/- mice. The TDO-AHR pathway is active in human brain tumors and is associated with malignant progression and poor survival. Activity within ROR-gamma-t-positive ILC could be induced by dietary ligands such as those contained in vegetables of the family Brassicaceae.

UniProt: P35869

Pathways: Regulation of Cell Size